Age-related differences in water and sodium handling after commercial hydration beverage ingestion

S. Tony Wolf, Anna E. Stanhewicz, Megan M. Clarke, Samuel N. Cheuvront, Robert W. Kenefick, William Lawrence Kenney, Jr.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aging is associated with altered water, electrolyte, and glucose handling. Alternative beverages to those containing carbohydrate (CHO) should be considered for older adults. We hypothesized that reduced sodium (CNa) and/or water (CH2O) clearance would underlie greater beverage retention in older compared with young adults, secondary to reduced glomerular filtration rate (GFR). We further hypothesized that amino acid (AA)- and CHO-based beverages would promote retention better than water. Over five visits, 12 young (23 3 yr; 7 men, 5 women) and 12 older (67 6 yr; 5 men, 7 women) subjects consumed 1 liter of distilled water or beverages with 6% CHO, 0.46 g/l Na [Gatorade (GAT)]; 2.5% CHO, 0.74 g/l Na [Pedialyte (PED)]; 5 AA, 1.04 g/l Na [enterade (ENT)-5]; or 8 AA, 1.38 g/l Na (ENT-8) over 30 min. Blood and urine were collected every hour for 4 h after ingestion; retention, CH2O, and CNa were calculated at 2 and 4 h. Additional calculations adjusted CH2O and CNa for estimated GFR (eGFR). Water yielded the lowest retention in both groups (P 0.02). Retention was higher in older vs. young adults except for ENT-8 at 4 h (P 0.73). CH2O was higher for older vs. young adults for GAT at 2 h (P 0.01) and GAT and PED at 4 h (P 0.01) after ingestion but was otherwise similar between groups. CNa was lower in older vs. young adults except for ENT-8 (P 0.19). Adjusting for eGFR resulted in higher CH2O for all beverages in older vs. young adults (P 0.05) but did not influence CNa. Older adults may better retain beverages with less Na than young adults because of reduced CNa. AA- and CHO-based electrolyte-rich beverages may similarly promote beverage retention.

Original languageEnglish (US)
Pages (from-to)1042-1048
Number of pages7
JournalJournal of Applied Physiology
Volume126
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Beverages
Eating
Sodium
Young Adult
Water
Amino Acids
Glomerular Filtration Rate
Electrolytes
Carbohydrates
Urine
Glucose

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Tony Wolf, S. ; Stanhewicz, Anna E. ; Clarke, Megan M. ; Cheuvront, Samuel N. ; Kenefick, Robert W. ; Kenney, Jr., William Lawrence. / Age-related differences in water and sodium handling after commercial hydration beverage ingestion. In: Journal of Applied Physiology. 2019 ; Vol. 126, No. 4. pp. 1042-1048.
@article{35cf51023e89487c9e68d7a68ab0b8a7,
title = "Age-related differences in water and sodium handling after commercial hydration beverage ingestion",
abstract = "Aging is associated with altered water, electrolyte, and glucose handling. Alternative beverages to those containing carbohydrate (CHO) should be considered for older adults. We hypothesized that reduced sodium (CNa) and/or water (CH2O) clearance would underlie greater beverage retention in older compared with young adults, secondary to reduced glomerular filtration rate (GFR). We further hypothesized that amino acid (AA)- and CHO-based beverages would promote retention better than water. Over five visits, 12 young (23 3 yr; 7 men, 5 women) and 12 older (67 6 yr; 5 men, 7 women) subjects consumed 1 liter of distilled water or beverages with 6{\%} CHO, 0.46 g/l Na [Gatorade (GAT)]; 2.5{\%} CHO, 0.74 g/l Na [Pedialyte (PED)]; 5 AA, 1.04 g/l Na [enterade (ENT)-5]; or 8 AA, 1.38 g/l Na (ENT-8) over 30 min. Blood and urine were collected every hour for 4 h after ingestion; retention, CH2O, and CNa were calculated at 2 and 4 h. Additional calculations adjusted CH2O and CNa for estimated GFR (eGFR). Water yielded the lowest retention in both groups (P 0.02). Retention was higher in older vs. young adults except for ENT-8 at 4 h (P 0.73). CH2O was higher for older vs. young adults for GAT at 2 h (P 0.01) and GAT and PED at 4 h (P 0.01) after ingestion but was otherwise similar between groups. CNa was lower in older vs. young adults except for ENT-8 (P 0.19). Adjusting for eGFR resulted in higher CH2O for all beverages in older vs. young adults (P 0.05) but did not influence CNa. Older adults may better retain beverages with less Na than young adults because of reduced CNa. AA- and CHO-based electrolyte-rich beverages may similarly promote beverage retention.",
author = "{Tony Wolf}, S. and Stanhewicz, {Anna E.} and Clarke, {Megan M.} and Cheuvront, {Samuel N.} and Kenefick, {Robert W.} and {Kenney, Jr.}, {William Lawrence}",
year = "2019",
month = "1",
day = "1",
doi = "10.1152/japplphysiol.01094.2018",
language = "English (US)",
volume = "126",
pages = "1042--1048",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "4",

}

Age-related differences in water and sodium handling after commercial hydration beverage ingestion. / Tony Wolf, S.; Stanhewicz, Anna E.; Clarke, Megan M.; Cheuvront, Samuel N.; Kenefick, Robert W.; Kenney, Jr., William Lawrence.

In: Journal of Applied Physiology, Vol. 126, No. 4, 01.01.2019, p. 1042-1048.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-related differences in water and sodium handling after commercial hydration beverage ingestion

AU - Tony Wolf, S.

AU - Stanhewicz, Anna E.

AU - Clarke, Megan M.

AU - Cheuvront, Samuel N.

AU - Kenefick, Robert W.

AU - Kenney, Jr., William Lawrence

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aging is associated with altered water, electrolyte, and glucose handling. Alternative beverages to those containing carbohydrate (CHO) should be considered for older adults. We hypothesized that reduced sodium (CNa) and/or water (CH2O) clearance would underlie greater beverage retention in older compared with young adults, secondary to reduced glomerular filtration rate (GFR). We further hypothesized that amino acid (AA)- and CHO-based beverages would promote retention better than water. Over five visits, 12 young (23 3 yr; 7 men, 5 women) and 12 older (67 6 yr; 5 men, 7 women) subjects consumed 1 liter of distilled water or beverages with 6% CHO, 0.46 g/l Na [Gatorade (GAT)]; 2.5% CHO, 0.74 g/l Na [Pedialyte (PED)]; 5 AA, 1.04 g/l Na [enterade (ENT)-5]; or 8 AA, 1.38 g/l Na (ENT-8) over 30 min. Blood and urine were collected every hour for 4 h after ingestion; retention, CH2O, and CNa were calculated at 2 and 4 h. Additional calculations adjusted CH2O and CNa for estimated GFR (eGFR). Water yielded the lowest retention in both groups (P 0.02). Retention was higher in older vs. young adults except for ENT-8 at 4 h (P 0.73). CH2O was higher for older vs. young adults for GAT at 2 h (P 0.01) and GAT and PED at 4 h (P 0.01) after ingestion but was otherwise similar between groups. CNa was lower in older vs. young adults except for ENT-8 (P 0.19). Adjusting for eGFR resulted in higher CH2O for all beverages in older vs. young adults (P 0.05) but did not influence CNa. Older adults may better retain beverages with less Na than young adults because of reduced CNa. AA- and CHO-based electrolyte-rich beverages may similarly promote beverage retention.

AB - Aging is associated with altered water, electrolyte, and glucose handling. Alternative beverages to those containing carbohydrate (CHO) should be considered for older adults. We hypothesized that reduced sodium (CNa) and/or water (CH2O) clearance would underlie greater beverage retention in older compared with young adults, secondary to reduced glomerular filtration rate (GFR). We further hypothesized that amino acid (AA)- and CHO-based beverages would promote retention better than water. Over five visits, 12 young (23 3 yr; 7 men, 5 women) and 12 older (67 6 yr; 5 men, 7 women) subjects consumed 1 liter of distilled water or beverages with 6% CHO, 0.46 g/l Na [Gatorade (GAT)]; 2.5% CHO, 0.74 g/l Na [Pedialyte (PED)]; 5 AA, 1.04 g/l Na [enterade (ENT)-5]; or 8 AA, 1.38 g/l Na (ENT-8) over 30 min. Blood and urine were collected every hour for 4 h after ingestion; retention, CH2O, and CNa were calculated at 2 and 4 h. Additional calculations adjusted CH2O and CNa for estimated GFR (eGFR). Water yielded the lowest retention in both groups (P 0.02). Retention was higher in older vs. young adults except for ENT-8 at 4 h (P 0.73). CH2O was higher for older vs. young adults for GAT at 2 h (P 0.01) and GAT and PED at 4 h (P 0.01) after ingestion but was otherwise similar between groups. CNa was lower in older vs. young adults except for ENT-8 (P 0.19). Adjusting for eGFR resulted in higher CH2O for all beverages in older vs. young adults (P 0.05) but did not influence CNa. Older adults may better retain beverages with less Na than young adults because of reduced CNa. AA- and CHO-based electrolyte-rich beverages may similarly promote beverage retention.

UR - http://www.scopus.com/inward/record.url?scp=85064880035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064880035&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.01094.2018

DO - 10.1152/japplphysiol.01094.2018

M3 - Article

C2 - 30763158

AN - SCOPUS:85064880035

VL - 126

SP - 1042

EP - 1048

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -