Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia

Yin Lin, Mingli Li, Yi Zhou, Wei Deng, Xiaohong Ma, Qiang Wang, Wanjun Guo, Yinfei Li, Lijun Jiang, Xun Hu, Nanyin Zhang, Tao Li

Research output: Contribution to journalArticle

Abstract

Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia. Meanwhile, progressive neurodegenerative processes have also been reported, leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia. However, a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures. To clarify this potential confounding factor, we measured the cortical thickness across the whole brain using high-resolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naïve patients with schizophrenia and 147 healthy controls. The results showed that, in the patient group, the frontal, temporal, parietal, and cingulate gyri displayed a significant age-related reduction of cortical thickness. In the control group, age-related cortical thickness reduction was mostly located in the frontal, temporal, and cingulate gyri, albeit to a lesser extent. Importantly, relative to healthy controls, patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate, inferior temporal, and insular gyri in the right hemisphere. These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness.

Original languageEnglish (US)
Pages (from-to)688-696
Number of pages9
JournalNeuroscience Bulletin
Volume35
Issue number4
DOIs
StatePublished - Aug 1 2019

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Gyrus Cinguli
Schizophrenia
Temporal Lobe
Brain
Therapeutics
Antipsychotic Agents
Magnetic Resonance Imaging
Control Groups

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Lin, Yin ; Li, Mingli ; Zhou, Yi ; Deng, Wei ; Ma, Xiaohong ; Wang, Qiang ; Guo, Wanjun ; Li, Yinfei ; Jiang, Lijun ; Hu, Xun ; Zhang, Nanyin ; Li, Tao. / Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia. In: Neuroscience Bulletin. 2019 ; Vol. 35, No. 4. pp. 688-696.
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abstract = "Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia. Meanwhile, progressive neurodegenerative processes have also been reported, leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia. However, a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures. To clarify this potential confounding factor, we measured the cortical thickness across the whole brain using high-resolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-na{\"i}ve patients with schizophrenia and 147 healthy controls. The results showed that, in the patient group, the frontal, temporal, parietal, and cingulate gyri displayed a significant age-related reduction of cortical thickness. In the control group, age-related cortical thickness reduction was mostly located in the frontal, temporal, and cingulate gyri, albeit to a lesser extent. Importantly, relative to healthy controls, patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate, inferior temporal, and insular gyri in the right hemisphere. These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness.",
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Lin, Y, Li, M, Zhou, Y, Deng, W, Ma, X, Wang, Q, Guo, W, Li, Y, Jiang, L, Hu, X, Zhang, N & Li, T 2019, 'Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia', Neuroscience Bulletin, vol. 35, no. 4, pp. 688-696. https://doi.org/10.1007/s12264-019-00348-x

Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia. / Lin, Yin; Li, Mingli; Zhou, Yi; Deng, Wei; Ma, Xiaohong; Wang, Qiang; Guo, Wanjun; Li, Yinfei; Jiang, Lijun; Hu, Xun; Zhang, Nanyin; Li, Tao.

In: Neuroscience Bulletin, Vol. 35, No. 4, 01.08.2019, p. 688-696.

Research output: Contribution to journalArticle

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AU - Ma, Xiaohong

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