Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep

Raina K. Plowright, Kezia R. Manlove, Thomas E. Besser, David J. Páez, Kimberly R. Andrews, Patrick E. Matthews, Lisette P. Waits, Peter J. Hudson, E. Frances Cassirer

Research output: Contribution to journalLetter

8 Citations (Scopus)

Abstract

Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free-ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age-structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation.

Original languageEnglish (US)
Pages (from-to)1325-1336
Number of pages12
JournalEcology Letters
Volume20
Issue number10
DOIs
StatePublished - Oct 2017

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Ovis canadensis
pneumonia
sheep
infection
Mycoplasma ovipneumoniae
age structure
public health
livestock
wildlife
loci

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Cite this

Plowright, R. K., Manlove, K. R., Besser, T. E., Páez, D. J., Andrews, K. R., Matthews, P. E., ... Cassirer, E. F. (2017). Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep. Ecology Letters, 20(10), 1325-1336. https://doi.org/10.1111/ele.12829
Plowright, Raina K. ; Manlove, Kezia R. ; Besser, Thomas E. ; Páez, David J. ; Andrews, Kimberly R. ; Matthews, Patrick E. ; Waits, Lisette P. ; Hudson, Peter J. ; Cassirer, E. Frances. / Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep. In: Ecology Letters. 2017 ; Vol. 20, No. 10. pp. 1325-1336.
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Plowright, RK, Manlove, KR, Besser, TE, Páez, DJ, Andrews, KR, Matthews, PE, Waits, LP, Hudson, PJ & Cassirer, EF 2017, 'Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep', Ecology Letters, vol. 20, no. 10, pp. 1325-1336. https://doi.org/10.1111/ele.12829

Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep. / Plowright, Raina K.; Manlove, Kezia R.; Besser, Thomas E.; Páez, David J.; Andrews, Kimberly R.; Matthews, Patrick E.; Waits, Lisette P.; Hudson, Peter J.; Cassirer, E. Frances.

In: Ecology Letters, Vol. 20, No. 10, 10.2017, p. 1325-1336.

Research output: Contribution to journalLetter

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AU - Andrews, Kimberly R.

AU - Matthews, Patrick E.

AU - Waits, Lisette P.

AU - Hudson, Peter J.

AU - Cassirer, E. Frances

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Plowright RK, Manlove KR, Besser TE, Páez DJ, Andrews KR, Matthews PE et al. Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep. Ecology Letters. 2017 Oct;20(10):1325-1336. https://doi.org/10.1111/ele.12829