Aggressive therapy reduces disease activity without skeletal damage progression in chronic nonbacterial osteomyelitis

Yongdong Zhao, Nancy A. Chauvin, Diego Jaramillo, Jon M. Burnham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective. To retrospectively assess changes in disease activity and skeletal damage in children with chronic nonbacterial osteomyelitis (CNO) after infliximab and methotrexate, with or without zoledronic acid or nonsteroidal antiinflammatory drug (NSAID) monotherapy, using a standardized magnetic resonance imaging (MRI) approach. Methods. Treatment-related changes in clinical and MRI measures from aggressive therapy and NSAID monotherapy groups (n = 9 per group) were evaluated using nonparametric methods. Results. Pain, physical function, physician global assessment, inflammatory markers, nonvertebral inflammatory lesion number, and maximum bone edema score all improved significantly with aggressive therapy (p < 0.03), whereas only the maximum soft tissue inflammation severity decreased (p = 0.02) with NSAID monotherapy. Vertebral deformities and physeal damage did not worsen in the aggressive therapy group but 1 in the NSAID group had worsening of growth plate damage. Conclusion. An aggressive treatment regimen in CNO improved clinical and imaging measures of disease activity without progression of skeletal damage.

Original languageEnglish (US)
Pages (from-to)1245-1251
Number of pages7
JournalJournal of Rheumatology
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2015

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Osteomyelitis
Anti-Inflammatory Agents
zoledronic acid
Pharmaceutical Preparations
Magnetic Resonance Imaging
Growth Plate
Therapeutics
Group Psychotherapy
Methotrexate
Edema
Inflammation
Physicians
Bone and Bones
Pain

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "Objective. To retrospectively assess changes in disease activity and skeletal damage in children with chronic nonbacterial osteomyelitis (CNO) after infliximab and methotrexate, with or without zoledronic acid or nonsteroidal antiinflammatory drug (NSAID) monotherapy, using a standardized magnetic resonance imaging (MRI) approach. Methods. Treatment-related changes in clinical and MRI measures from aggressive therapy and NSAID monotherapy groups (n = 9 per group) were evaluated using nonparametric methods. Results. Pain, physical function, physician global assessment, inflammatory markers, nonvertebral inflammatory lesion number, and maximum bone edema score all improved significantly with aggressive therapy (p < 0.03), whereas only the maximum soft tissue inflammation severity decreased (p = 0.02) with NSAID monotherapy. Vertebral deformities and physeal damage did not worsen in the aggressive therapy group but 1 in the NSAID group had worsening of growth plate damage. Conclusion. An aggressive treatment regimen in CNO improved clinical and imaging measures of disease activity without progression of skeletal damage.",
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Aggressive therapy reduces disease activity without skeletal damage progression in chronic nonbacterial osteomyelitis. / Zhao, Yongdong; Chauvin, Nancy A.; Jaramillo, Diego; Burnham, Jon M.

In: Journal of Rheumatology, Vol. 42, No. 7, 01.07.2015, p. 1245-1251.

Research output: Contribution to journalArticle

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