Aging and the control of human skin blood flow

Lacy A. Holowatz, Caitlin Thompson-Torgerson, W. Larry Kenney

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Human exposure to cold and heat stimulates cutaneous vasoconstriction and vasodilation via distinct sympathetic reflex and locally mediated pathways. The mechanisms mediating cutaneous vasoconstriction and vasodilation are impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness, respectively. This paper highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairments, whereas changes in local intracellular signaling suggest a more generalized age-associated vascular dysfunction.

Original languageEnglish (US)
Pages (from-to)718-739
Number of pages22
JournalFrontiers in Bioscience
Issue number2
StatePublished - Jan 1 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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