Aging in the olfactory system

Arie S. Mobley, Diego J. Rodriguez-Gil, Fumiaki Imamura, Charles A. Greer

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

With advancing age, the ability of humans to detect and discriminate odors declines. In light of the rapid progress in analyzing molecular and structural correlates of developing and adult olfactory systems, the paucity of information available on the aged olfactory system is startling. A rich literature documents the decline of olfactory acuity in aged humans, but the underlying cellular and molecular mechanisms are largely unknown. Using animal models, preliminary work is beginning to uncover differences between young and aged rodents that may help address the deficits seen in humans, but many questions remain unanswered. Recent studies of odorant receptor (OR) expression, synaptic organization, adult neurogenesis, and the contribution of cortical representation during aging suggest possible underlying mechanisms and new research directions.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalTrends in Neurosciences
Volume37
Issue number2
DOIs
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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