Aging increases venous compliance in awake instrumented rats

M. R. Glick, J. D. Gehman, J. A. Gascho

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

To determine the effects of aging on total venous compliance, mean circulatory filling pressure (MCFP) was determined at several different blood volumes in 10 young (10-mo-old) and 10 older (30-mo-old) awake instrumented male Fischer 344/Brown Norway hybrid rats. Baseline weight and mean arterial pressure were similar in the two groups; heart rate was higher in the young (426 ± 9 beats/min) than in the older rats (376 ± 8 beats/min). Although MCFP was similar in the two groups at baseline blood volume, MCFP rose less with transient volume expansion and fell less with transient volume depletion in the older rats. The calculated venous compliance (reciprocal of the slope of the MCFP-to-volume relation) for the older rats was 25% greater than in the younger rats (3.28 ± 0.21 vs. 2.63 ± 0.12 ml · kg-1 · mmHg-1; P = 0.014). In this conscious instrumented rat model, baseline total venous compliance is increased in older rats.

Original languageEnglish (US)
Pages (from-to)H1948-H1952
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume264
Issue number6 33-6
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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