Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects

Joseph Gascho, Claude Fanelli, Robert Zelis

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.

Original languageEnglish (US)
Pages (from-to)1267-1270
Number of pages4
JournalThe American journal of cardiology
Volume63
Issue number17
DOIs
StatePublished - May 15 1989

Fingerprint

Nitroglycerin
Arterial Pressure
Arm
Economic Inflation
Heart Rate

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{9136c670813d4840871eb04a878e959b,
title = "Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects",
abstract = "To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.",
author = "Joseph Gascho and Claude Fanelli and Robert Zelis",
year = "1989",
month = "5",
day = "15",
doi = "10.1016/0002-9149(89)90188-4",
language = "English (US)",
volume = "63",
pages = "1267--1270",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "17",

}

Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects. / Gascho, Joseph; Fanelli, Claude; Zelis, Robert.

In: The American journal of cardiology, Vol. 63, No. 17, 15.05.1989, p. 1267-1270.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects

AU - Gascho, Joseph

AU - Fanelli, Claude

AU - Zelis, Robert

PY - 1989/5/15

Y1 - 1989/5/15

N2 - To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.

AB - To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.

UR - http://www.scopus.com/inward/record.url?scp=0024554481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024554481&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(89)90188-4

DO - 10.1016/0002-9149(89)90188-4

M3 - Article

VL - 63

SP - 1267

EP - 1270

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 17

ER -