TY - JOUR
T1 - Alaskan wild berry resources and human health under the cloud of climate change
AU - Kellogg, Joshua
AU - Wang, Jinzhi
AU - Flint, Courtney
AU - Ribnicky, David
AU - Kuhn, Peter
AU - De Mejia, Elvira González
AU - Raskin, Ilya
AU - Lila, Mary Ann
PY - 2010/4/14
Y1 - 2010/4/14
N2 - Wild berries are integral dietary components for Alaska Native people and a rich source of polyphenolic metabolites that can ameliorate metabolic disorders such as obesity and diabetes. In this study, five species of wild Alaskan berries (Vaccinium ovalifolium, Vaccinium uliginosum, Rubus chamaemorus, Rubus spectabilis, and Empetrum nigrum) were screened for bioactivity through a community-participatory research method involving three geographically distinct tribal communities. Compositional analysis by HPLC and LC-MS2 revealed substantial site-specific variation in anthocyanins (0.01?4.39 mg/g of FW) and proanthocyanidins (0.74?6.25 mg/g of FW) and identified A-type proanthocyanidin polymers. R. spectabilis increased expression levels of preadipocyte factor 1 (182%), and proanthocyanidin-enriched fractions from other species reduced lipid accumulation in 3T3-L1 adipocytes. Selected extracts reduced serum glucose levels in C57BL/6J mice by up to 45%. Local observations provided robust insights into effects of climatic fluctuations on berry abundance and quality, and preliminary site-specific compositional and bioactivity differences were noted, suggesting the need to monitor this Alaska Native resource as climate shifts affect the region.
AB - Wild berries are integral dietary components for Alaska Native people and a rich source of polyphenolic metabolites that can ameliorate metabolic disorders such as obesity and diabetes. In this study, five species of wild Alaskan berries (Vaccinium ovalifolium, Vaccinium uliginosum, Rubus chamaemorus, Rubus spectabilis, and Empetrum nigrum) were screened for bioactivity through a community-participatory research method involving three geographically distinct tribal communities. Compositional analysis by HPLC and LC-MS2 revealed substantial site-specific variation in anthocyanins (0.01?4.39 mg/g of FW) and proanthocyanidins (0.74?6.25 mg/g of FW) and identified A-type proanthocyanidin polymers. R. spectabilis increased expression levels of preadipocyte factor 1 (182%), and proanthocyanidin-enriched fractions from other species reduced lipid accumulation in 3T3-L1 adipocytes. Selected extracts reduced serum glucose levels in C57BL/6J mice by up to 45%. Local observations provided robust insights into effects of climatic fluctuations on berry abundance and quality, and preliminary site-specific compositional and bioactivity differences were noted, suggesting the need to monitor this Alaska Native resource as climate shifts affect the region.
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U2 - 10.1021/jf902693r
DO - 10.1021/jf902693r
M3 - Article
C2 - 20025229
AN - SCOPUS:77950688494
VL - 58
SP - 3884
EP - 3900
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 7
ER -