Alcohol-Induced Changes in the GH-IGF Axis

Charles H. Lang, Robert A. Frost

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter describes the effect of alcohol in the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis. Acute alcohol intoxication and chronic alcohol consumption leads to the profound endocrine dysfunction and the most pronounced alcohol-induced effects is the alteration in the GH-IGF axis. Abundant experimental evidence indicates that the pulsatile secretion of GH is suppressed in response to both acute and chronic alcohol abuse. Alcohol also dramatically influences various elements of the IGF system. In this regard, chronic alcohol consumption is uniformly demonstrated to decrease the circulating concentration of IGF-I independent of a difference in nutritional status. While this alcohol-induced decrease in blood-borne IGF-I results primarily from a reduction in hepatic IGF-I synthesis and secretion, IGF-I mRNA and protein content are also reduced in a number of extrahepatic tissues (e.g. skeletal muscle). Moreover, the alcohol-induced decrease in the muscle IGF-I is positively correlated to a reduction in the protein synthetic rate of this tissue. The large majority of lGF-I in the circulation is bound to one of the six high-affinity binding proteins (IGFBPs). Of these carriers, alcohol produces its greatest effect on IGFBP-1, as evidenced by the several-fold increase in IGFBP-1 concentration in blood, liver, and kidney.

Original languageEnglish (US)
Title of host publicationComprehensive Handbook of Alcohol Related Pathology
PublisherElsevier Inc.
Pages991-1005
Number of pages15
Volume2-3
ISBN (Electronic)9780080502311
ISBN (Print)9780125643702
DOIs
StatePublished - Dec 30 2004

Fingerprint

Somatomedins
Growth Hormone
Insulin-Like Growth Factor I
Alcohols
Insulin-Like Growth Factor Binding Protein 1
Alcohol Drinking
Alcoholic Intoxication
Insulin-Like Growth Factor Binding Proteins
Liver
Muscle
Nutritional Status
Blood
Alcoholism
Tissue
Carrier Proteins
Skeletal Muscle
Proteins
Kidney
Muscles
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lang, C. H., & Frost, R. A. (2004). Alcohol-Induced Changes in the GH-IGF Axis. In Comprehensive Handbook of Alcohol Related Pathology (Vol. 2-3, pp. 991-1005). Elsevier Inc.. https://doi.org/10.1016/B978-012564370-2/50079-9
Lang, Charles H. ; Frost, Robert A. / Alcohol-Induced Changes in the GH-IGF Axis. Comprehensive Handbook of Alcohol Related Pathology. Vol. 2-3 Elsevier Inc., 2004. pp. 991-1005
@inbook{5497c86844014fe6babfb8027d99e181,
title = "Alcohol-Induced Changes in the GH-IGF Axis",
abstract = "This chapter describes the effect of alcohol in the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis. Acute alcohol intoxication and chronic alcohol consumption leads to the profound endocrine dysfunction and the most pronounced alcohol-induced effects is the alteration in the GH-IGF axis. Abundant experimental evidence indicates that the pulsatile secretion of GH is suppressed in response to both acute and chronic alcohol abuse. Alcohol also dramatically influences various elements of the IGF system. In this regard, chronic alcohol consumption is uniformly demonstrated to decrease the circulating concentration of IGF-I independent of a difference in nutritional status. While this alcohol-induced decrease in blood-borne IGF-I results primarily from a reduction in hepatic IGF-I synthesis and secretion, IGF-I mRNA and protein content are also reduced in a number of extrahepatic tissues (e.g. skeletal muscle). Moreover, the alcohol-induced decrease in the muscle IGF-I is positively correlated to a reduction in the protein synthetic rate of this tissue. The large majority of lGF-I in the circulation is bound to one of the six high-affinity binding proteins (IGFBPs). Of these carriers, alcohol produces its greatest effect on IGFBP-1, as evidenced by the several-fold increase in IGFBP-1 concentration in blood, liver, and kidney.",
author = "Lang, {Charles H.} and Frost, {Robert A.}",
year = "2004",
month = "12",
day = "30",
doi = "10.1016/B978-012564370-2/50079-9",
language = "English (US)",
isbn = "9780125643702",
volume = "2-3",
pages = "991--1005",
booktitle = "Comprehensive Handbook of Alcohol Related Pathology",
publisher = "Elsevier Inc.",
address = "United States",

}

Lang, CH & Frost, RA 2004, Alcohol-Induced Changes in the GH-IGF Axis. in Comprehensive Handbook of Alcohol Related Pathology. vol. 2-3, Elsevier Inc., pp. 991-1005. https://doi.org/10.1016/B978-012564370-2/50079-9

Alcohol-Induced Changes in the GH-IGF Axis. / Lang, Charles H.; Frost, Robert A.

Comprehensive Handbook of Alcohol Related Pathology. Vol. 2-3 Elsevier Inc., 2004. p. 991-1005.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Alcohol-Induced Changes in the GH-IGF Axis

AU - Lang, Charles H.

AU - Frost, Robert A.

PY - 2004/12/30

Y1 - 2004/12/30

N2 - This chapter describes the effect of alcohol in the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis. Acute alcohol intoxication and chronic alcohol consumption leads to the profound endocrine dysfunction and the most pronounced alcohol-induced effects is the alteration in the GH-IGF axis. Abundant experimental evidence indicates that the pulsatile secretion of GH is suppressed in response to both acute and chronic alcohol abuse. Alcohol also dramatically influences various elements of the IGF system. In this regard, chronic alcohol consumption is uniformly demonstrated to decrease the circulating concentration of IGF-I independent of a difference in nutritional status. While this alcohol-induced decrease in blood-borne IGF-I results primarily from a reduction in hepatic IGF-I synthesis and secretion, IGF-I mRNA and protein content are also reduced in a number of extrahepatic tissues (e.g. skeletal muscle). Moreover, the alcohol-induced decrease in the muscle IGF-I is positively correlated to a reduction in the protein synthetic rate of this tissue. The large majority of lGF-I in the circulation is bound to one of the six high-affinity binding proteins (IGFBPs). Of these carriers, alcohol produces its greatest effect on IGFBP-1, as evidenced by the several-fold increase in IGFBP-1 concentration in blood, liver, and kidney.

AB - This chapter describes the effect of alcohol in the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis. Acute alcohol intoxication and chronic alcohol consumption leads to the profound endocrine dysfunction and the most pronounced alcohol-induced effects is the alteration in the GH-IGF axis. Abundant experimental evidence indicates that the pulsatile secretion of GH is suppressed in response to both acute and chronic alcohol abuse. Alcohol also dramatically influences various elements of the IGF system. In this regard, chronic alcohol consumption is uniformly demonstrated to decrease the circulating concentration of IGF-I independent of a difference in nutritional status. While this alcohol-induced decrease in blood-borne IGF-I results primarily from a reduction in hepatic IGF-I synthesis and secretion, IGF-I mRNA and protein content are also reduced in a number of extrahepatic tissues (e.g. skeletal muscle). Moreover, the alcohol-induced decrease in the muscle IGF-I is positively correlated to a reduction in the protein synthetic rate of this tissue. The large majority of lGF-I in the circulation is bound to one of the six high-affinity binding proteins (IGFBPs). Of these carriers, alcohol produces its greatest effect on IGFBP-1, as evidenced by the several-fold increase in IGFBP-1 concentration in blood, liver, and kidney.

UR - http://www.scopus.com/inward/record.url?scp=84943235366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943235366&partnerID=8YFLogxK

U2 - 10.1016/B978-012564370-2/50079-9

DO - 10.1016/B978-012564370-2/50079-9

M3 - Chapter

AN - SCOPUS:84943235366

SN - 9780125643702

VL - 2-3

SP - 991

EP - 1005

BT - Comprehensive Handbook of Alcohol Related Pathology

PB - Elsevier Inc.

ER -

Lang CH, Frost RA. Alcohol-Induced Changes in the GH-IGF Axis. In Comprehensive Handbook of Alcohol Related Pathology. Vol. 2-3. Elsevier Inc. 2004. p. 991-1005 https://doi.org/10.1016/B978-012564370-2/50079-9