This chapter describes the effect of alcohol in the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis. Acute alcohol intoxication and chronic alcohol consumption leads to the profound endocrine dysfunction and the most pronounced alcohol-induced effects is the alteration in the GH-IGF axis. Abundant experimental evidence indicates that the pulsatile secretion of GH is suppressed in response to both acute and chronic alcohol abuse. Alcohol also dramatically influences various elements of the IGF system. In this regard, chronic alcohol consumption is uniformly demonstrated to decrease the circulating concentration of IGF-I independent of a difference in nutritional status. While this alcohol-induced decrease in blood-borne IGF-I results primarily from a reduction in hepatic IGF-I synthesis and secretion, IGF-I mRNA and protein content are also reduced in a number of extrahepatic tissues (e.g. skeletal muscle). Moreover, the alcohol-induced decrease in the muscle IGF-I is positively correlated to a reduction in the protein synthetic rate of this tissue. The large majority of lGF-I in the circulation is bound to one of the six high-affinity binding proteins (IGFBPs). Of these carriers, alcohol produces its greatest effect on IGFBP-1, as evidenced by the several-fold increase in IGFBP-1 concentration in blood, liver, and kidney.
|Original language||English (US)|
|Title of host publication||Comprehensive Handbook of Alcohol Related Pathology|
|Number of pages||15|
|State||Published - Dec 30 2004|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)