Alcohol pretreatment alters the metabolic pattern and accelerates cocaine metabolism in pigs

Jay R. Kambam, John J. Franks, Piotr Janicki, Berend Mets, Marylyn vd Watt, Rosemary Hickman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We investigated whether alcohol pretreatment would affect the disposition and metabolic pattern of intravenously (i.v.) administered cocaine in pigs. Six pigs (Group A) received alcohol (1 g/kg/day) and six pigs (control; Group D) received an equal volume of isocaloric dextrose 44% in water for 10 days via an intragastric tube. On day 11, arterial samples were taken for five hours following an intravenous administration of cocaine hydrochloride (4 mg/kg). Plasma concentrations of cocaine and its major metabolites were analyzed by HPLC method. Significant decrease in plasma half-life (10 ± 1.2 vs. 18.7 ± 1.4 min), and significant increases in apparent volume of distribution (73 ± 6 vs. 51 ± 31) and clearance (5.37 ± 0.6 vs. 1.82 ± 0.1 1/min) were seen in alcohol pretreated pigs as compared with control pigs (P < 0.05). Significant increases in plasma concentrations of benzoylecgonine (P < 0.05), and insignificant differences in ecgonine methyl ester and norcocaine levels were seen between the two groups. Neither ecgonine nor cocaethylene was detected in the blood samples. Our data show that alcohol administration for ten days accelerated the elimination of i.v. administered cocaine and altered its metabolic pattern in pigs.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalDrug and Alcohol Dependence
Volume36
Issue number1
DOIs
StatePublished - Jan 1 1994

Fingerprint

Cocaine
Metabolism
Swine
alcohol
Alcohols
Plasmas
Group
Metabolites
disposition
Blood
Glucose
Intravenous Administration
water
Half-Life
Water
High Pressure Liquid Chromatography
Control Groups

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kambam, Jay R. ; Franks, John J. ; Janicki, Piotr ; Mets, Berend ; Watt, Marylyn vd ; Hickman, Rosemary. / Alcohol pretreatment alters the metabolic pattern and accelerates cocaine metabolism in pigs. In: Drug and Alcohol Dependence. 1994 ; Vol. 36, No. 1. pp. 9-13.
@article{31ff18c7042241e9af726178eea53995,
title = "Alcohol pretreatment alters the metabolic pattern and accelerates cocaine metabolism in pigs",
abstract = "We investigated whether alcohol pretreatment would affect the disposition and metabolic pattern of intravenously (i.v.) administered cocaine in pigs. Six pigs (Group A) received alcohol (1 g/kg/day) and six pigs (control; Group D) received an equal volume of isocaloric dextrose 44{\%} in water for 10 days via an intragastric tube. On day 11, arterial samples were taken for five hours following an intravenous administration of cocaine hydrochloride (4 mg/kg). Plasma concentrations of cocaine and its major metabolites were analyzed by HPLC method. Significant decrease in plasma half-life (10 ± 1.2 vs. 18.7 ± 1.4 min), and significant increases in apparent volume of distribution (73 ± 6 vs. 51 ± 31) and clearance (5.37 ± 0.6 vs. 1.82 ± 0.1 1/min) were seen in alcohol pretreated pigs as compared with control pigs (P < 0.05). Significant increases in plasma concentrations of benzoylecgonine (P < 0.05), and insignificant differences in ecgonine methyl ester and norcocaine levels were seen between the two groups. Neither ecgonine nor cocaethylene was detected in the blood samples. Our data show that alcohol administration for ten days accelerated the elimination of i.v. administered cocaine and altered its metabolic pattern in pigs.",
author = "Kambam, {Jay R.} and Franks, {John J.} and Piotr Janicki and Berend Mets and Watt, {Marylyn vd} and Rosemary Hickman",
year = "1994",
month = "1",
day = "1",
doi = "10.1016/0376-8716(94)90003-5",
language = "English (US)",
volume = "36",
pages = "9--13",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Alcohol pretreatment alters the metabolic pattern and accelerates cocaine metabolism in pigs. / Kambam, Jay R.; Franks, John J.; Janicki, Piotr; Mets, Berend; Watt, Marylyn vd; Hickman, Rosemary.

In: Drug and Alcohol Dependence, Vol. 36, No. 1, 01.01.1994, p. 9-13.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol pretreatment alters the metabolic pattern and accelerates cocaine metabolism in pigs

AU - Kambam, Jay R.

AU - Franks, John J.

AU - Janicki, Piotr

AU - Mets, Berend

AU - Watt, Marylyn vd

AU - Hickman, Rosemary

PY - 1994/1/1

Y1 - 1994/1/1

N2 - We investigated whether alcohol pretreatment would affect the disposition and metabolic pattern of intravenously (i.v.) administered cocaine in pigs. Six pigs (Group A) received alcohol (1 g/kg/day) and six pigs (control; Group D) received an equal volume of isocaloric dextrose 44% in water for 10 days via an intragastric tube. On day 11, arterial samples were taken for five hours following an intravenous administration of cocaine hydrochloride (4 mg/kg). Plasma concentrations of cocaine and its major metabolites were analyzed by HPLC method. Significant decrease in plasma half-life (10 ± 1.2 vs. 18.7 ± 1.4 min), and significant increases in apparent volume of distribution (73 ± 6 vs. 51 ± 31) and clearance (5.37 ± 0.6 vs. 1.82 ± 0.1 1/min) were seen in alcohol pretreated pigs as compared with control pigs (P < 0.05). Significant increases in plasma concentrations of benzoylecgonine (P < 0.05), and insignificant differences in ecgonine methyl ester and norcocaine levels were seen between the two groups. Neither ecgonine nor cocaethylene was detected in the blood samples. Our data show that alcohol administration for ten days accelerated the elimination of i.v. administered cocaine and altered its metabolic pattern in pigs.

AB - We investigated whether alcohol pretreatment would affect the disposition and metabolic pattern of intravenously (i.v.) administered cocaine in pigs. Six pigs (Group A) received alcohol (1 g/kg/day) and six pigs (control; Group D) received an equal volume of isocaloric dextrose 44% in water for 10 days via an intragastric tube. On day 11, arterial samples were taken for five hours following an intravenous administration of cocaine hydrochloride (4 mg/kg). Plasma concentrations of cocaine and its major metabolites were analyzed by HPLC method. Significant decrease in plasma half-life (10 ± 1.2 vs. 18.7 ± 1.4 min), and significant increases in apparent volume of distribution (73 ± 6 vs. 51 ± 31) and clearance (5.37 ± 0.6 vs. 1.82 ± 0.1 1/min) were seen in alcohol pretreated pigs as compared with control pigs (P < 0.05). Significant increases in plasma concentrations of benzoylecgonine (P < 0.05), and insignificant differences in ecgonine methyl ester and norcocaine levels were seen between the two groups. Neither ecgonine nor cocaethylene was detected in the blood samples. Our data show that alcohol administration for ten days accelerated the elimination of i.v. administered cocaine and altered its metabolic pattern in pigs.

UR - http://www.scopus.com/inward/record.url?scp=0027956085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027956085&partnerID=8YFLogxK

U2 - 10.1016/0376-8716(94)90003-5

DO - 10.1016/0376-8716(94)90003-5

M3 - Article

C2 - 7988363

AN - SCOPUS:0027956085

VL - 36

SP - 9

EP - 13

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

IS - 1

ER -