Abstract
Purpose of review Alemtuzumab (Campath) usage as a preconditioning agent in kidney transplantation has gained considerable interest in the recent future. Alemtuzumab is currently available only by special request from Sanofi through its Campath distribution program. It is restricted to transplant programs with prior and continued experience with the agent. There may be a resurgence of interest for the utilization of this agent because of its ease of administration, and less cost and comparable or improved outcome in comparison to other induction agents. Recent findings Alemtuzumab when combined with standard calcineurin inhibitor and mycophenolate mofetil is well tolerated and efficacious as an induction therapy and allows for long-term steroid avoidance in high-risk renal transplant recipients. Summary The transplant community has advanced through a learning curve with the use of alemtuzumab over time; starting from an agent that was tried out to induce proper tolerance, minimization of nephrotoxic calcineurin inhibitors, and currently as a comparable depletional therapy that can reduce acute rejection in high-risk kidney transplant recipients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 638-642 |
| Number of pages | 5 |
| Journal | Current Opinion in Organ Transplantation |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2015 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Transplantation
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Alemtuzumab (Campath-1H) experience in kidney transplantation what we have learned; current practices; and scope for the future? / Gundroo, Aijaz; Zachariah, Mareena; Singh, Neeraj; Sharma, Rajeev.
In: Current Opinion in Organ Transplantation, Vol. 20, No. 6, 01.12.2015, p. 638-642.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Alemtuzumab (Campath-1H) experience in kidney transplantation what we have learned; current practices; and scope for the future?
AU - Gundroo, Aijaz
AU - Zachariah, Mareena
AU - Singh, Neeraj
AU - Sharma, Rajeev
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Purpose of review Alemtuzumab (Campath) usage as a preconditioning agent in kidney transplantation has gained considerable interest in the recent future. Alemtuzumab is currently available only by special request from Sanofi through its Campath distribution program. It is restricted to transplant programs with prior and continued experience with the agent. There may be a resurgence of interest for the utilization of this agent because of its ease of administration, and less cost and comparable or improved outcome in comparison to other induction agents. Recent findings Alemtuzumab when combined with standard calcineurin inhibitor and mycophenolate mofetil is well tolerated and efficacious as an induction therapy and allows for long-term steroid avoidance in high-risk renal transplant recipients. Summary The transplant community has advanced through a learning curve with the use of alemtuzumab over time; starting from an agent that was tried out to induce proper tolerance, minimization of nephrotoxic calcineurin inhibitors, and currently as a comparable depletional therapy that can reduce acute rejection in high-risk kidney transplant recipients.
AB - Purpose of review Alemtuzumab (Campath) usage as a preconditioning agent in kidney transplantation has gained considerable interest in the recent future. Alemtuzumab is currently available only by special request from Sanofi through its Campath distribution program. It is restricted to transplant programs with prior and continued experience with the agent. There may be a resurgence of interest for the utilization of this agent because of its ease of administration, and less cost and comparable or improved outcome in comparison to other induction agents. Recent findings Alemtuzumab when combined with standard calcineurin inhibitor and mycophenolate mofetil is well tolerated and efficacious as an induction therapy and allows for long-term steroid avoidance in high-risk renal transplant recipients. Summary The transplant community has advanced through a learning curve with the use of alemtuzumab over time; starting from an agent that was tried out to induce proper tolerance, minimization of nephrotoxic calcineurin inhibitors, and currently as a comparable depletional therapy that can reduce acute rejection in high-risk kidney transplant recipients.
UR - http://www.scopus.com/inward/record.url?scp=84961050724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961050724&partnerID=8YFLogxK
U2 - 10.1097/MOT.0000000000000255
DO - 10.1097/MOT.0000000000000255
M3 - Review article
VL - 20
SP - 638
EP - 642
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
SN - 1087-2418
IS - 6
ER -