Abstract
Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation of the gastrointestinal tract and an immune-mediated attack against the commensal microbiota. Vitamin D is an essential vitamin that not only promotes calcium and phosphate absorption but also regulates immune function. The active form of vitamin D [1,25(OH)2D] has been shown to suppress symptoms of IBD by inhibiting T cell responses. Host protection from gastrointestinal infection depends on T cells. Paradoxically, vitamin D deficiency increases susceptibility to IBD and gastrointestinal infection. Here we review the roles of vitamin D in immune cells using a kinetic model of the vitamin D-mediated effects on infection to explain the sometimes paradoxical effects of vitamin D on gastrointestinal immunity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 459-466 |
| Number of pages | 8 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
}
Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity. / Cantorna, Margherita Teresa-Anna; Rogers, Connie Jo; Arora, Juhi.
In: Trends in Endocrinology and Metabolism, Vol. 30, No. 7, 01.07.2019, p. 459-466.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity
AU - Cantorna, Margherita Teresa-Anna
AU - Rogers, Connie Jo
AU - Arora, Juhi
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation of the gastrointestinal tract and an immune-mediated attack against the commensal microbiota. Vitamin D is an essential vitamin that not only promotes calcium and phosphate absorption but also regulates immune function. The active form of vitamin D [1,25(OH)2D] has been shown to suppress symptoms of IBD by inhibiting T cell responses. Host protection from gastrointestinal infection depends on T cells. Paradoxically, vitamin D deficiency increases susceptibility to IBD and gastrointestinal infection. Here we review the roles of vitamin D in immune cells using a kinetic model of the vitamin D-mediated effects on infection to explain the sometimes paradoxical effects of vitamin D on gastrointestinal immunity.
AB - Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation of the gastrointestinal tract and an immune-mediated attack against the commensal microbiota. Vitamin D is an essential vitamin that not only promotes calcium and phosphate absorption but also regulates immune function. The active form of vitamin D [1,25(OH)2D] has been shown to suppress symptoms of IBD by inhibiting T cell responses. Host protection from gastrointestinal infection depends on T cells. Paradoxically, vitamin D deficiency increases susceptibility to IBD and gastrointestinal infection. Here we review the roles of vitamin D in immune cells using a kinetic model of the vitamin D-mediated effects on infection to explain the sometimes paradoxical effects of vitamin D on gastrointestinal immunity.
UR - http://www.scopus.com/inward/record.url?scp=85065793492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065793492&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2019.04.005
DO - 10.1016/j.tem.2019.04.005
M3 - Review article
C2 - 31122825
AN - SCOPUS:85065793492
VL - 30
SP - 459
EP - 466
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 7
ER -