Alkylfurans: Effects of alkyl side-chain length on insecticidal activity

Cesar R. Rodriguez-Saona, David F. Maynard, Scott Phillips, John T. Trumble

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The insecticidal activity of five alkylfurans against the generalist insect herbivore beet armyworm, Spodoptera exigua, was examined. Two naturally occurring compounds, the avocadofurans 2-(pentadecyl)furan (1) and 2-(heptadecyl)furan (2), previously isolated from specialized avocado idioblast oil cells, and three homologues, 2-(tetradecyl)furan (3), 2- (hexadecyl)furan (4), and 2-(octadecyl)furan (5), were synthesized. Bioassays of a1kylfurans 1-5 using a 9-day diet-incorporation initiated with neonates showed that all a1kylfurans tested significantly increased S. exigua larval mortality and reduced larval weights, with maximal biological activity detected among the naturally occurring alkylfurans 1 and 2.

Original languageEnglish (US)
Pages (from-to)191-193
Number of pages3
JournalJournal of Natural Products
Volume62
Issue number1
DOIs
StatePublished - Feb 16 1999

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Rodriguez-Saona, C. R., Maynard, D. F., Phillips, S., & Trumble, J. T. (1999). Alkylfurans: Effects of alkyl side-chain length on insecticidal activity. Journal of Natural Products, 62(1), 191-193. https://doi.org/10.1021/np980340m