All-night functional magnetic resonance imaging sleep studies

Thomas M. Moehlman, Jacco A. de Zwart, Miranda G. Chappel-Farley, Xiao Liu, Irene B. McClain, Catie Chang, Hendrik Mandelkow, Pinar S. Özbay, Nicholas L. Johnson, Rebecca E. Bieber, Katharine A. Fernandez, Kelly A. King, Christopher K. Zalewski, Carmen C. Brewer, Peter van Gelderen, Jeff H. Duyn, Dante Picchioni

Research output: Contribution to journalArticle

Abstract

Background: Previous functional magnetic resonance imaging (fMRI) sleep studies have been hampered by the difficulty of obtaining extended amounts of sleep in the sleep-adverse environment of the scanner and often have resorted to manipulations such as sleep depriving subjects before scanning. These manipulations limit the generalizability of the results. New method: The current study is a methodological validation of procedures aimed at obtaining all-night fMRI data in sleeping subjects with minimal exposure to experimentally induced sleep deprivation. Specifically, subjects slept in the scanner on two consecutive nights, allowing the first night to serve as an adaptation night. Results/comparison with existing method(s): Sleep scoring results from simultaneously acquired electroencephalography data on Night 2 indicate that subjects (n = 12) reached the full spectrum of sleep stages including slow-wave (M = 52.1 min, SD = 26.5 min) and rapid eye movement (REM, M = 45.2 min, SD = 27.9 min) sleep and exhibited a mean of 2.1 (SD = 1.1) nonREM-REM sleep cycles. Conclusions: It was found that by diligently applying fundamental principles and methodologies of sleep and neuroimaging science, performing all-night fMRI sleep studies is feasible. However, because the two nights of the study were performed consecutively, some sleep deprivation from Night 1 as a cause of the Night 2 results is likely, so consideration should be given to replicating the current study with a washout period. It is envisioned that other laboratories can adopt the core features of this protocol to obtain similar results.

Original languageEnglish (US)
Pages (from-to)83-98
Number of pages16
JournalJournal of Neuroscience Methods
Volume316
DOIs
StatePublished - Mar 15 2019

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Sleep
Magnetic Resonance Imaging
Sleep Deprivation
REM Sleep
Sleep Stages
Neuroimaging
Electroencephalography

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Moehlman, T. M., de Zwart, J. A., Chappel-Farley, M. G., Liu, X., McClain, I. B., Chang, C., ... Picchioni, D. (2019). All-night functional magnetic resonance imaging sleep studies. Journal of Neuroscience Methods, 316, 83-98. https://doi.org/10.1016/j.jneumeth.2018.09.019
Moehlman, Thomas M. ; de Zwart, Jacco A. ; Chappel-Farley, Miranda G. ; Liu, Xiao ; McClain, Irene B. ; Chang, Catie ; Mandelkow, Hendrik ; Özbay, Pinar S. ; Johnson, Nicholas L. ; Bieber, Rebecca E. ; Fernandez, Katharine A. ; King, Kelly A. ; Zalewski, Christopher K. ; Brewer, Carmen C. ; van Gelderen, Peter ; Duyn, Jeff H. ; Picchioni, Dante. / All-night functional magnetic resonance imaging sleep studies. In: Journal of Neuroscience Methods. 2019 ; Vol. 316. pp. 83-98.
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abstract = "Background: Previous functional magnetic resonance imaging (fMRI) sleep studies have been hampered by the difficulty of obtaining extended amounts of sleep in the sleep-adverse environment of the scanner and often have resorted to manipulations such as sleep depriving subjects before scanning. These manipulations limit the generalizability of the results. New method: The current study is a methodological validation of procedures aimed at obtaining all-night fMRI data in sleeping subjects with minimal exposure to experimentally induced sleep deprivation. Specifically, subjects slept in the scanner on two consecutive nights, allowing the first night to serve as an adaptation night. Results/comparison with existing method(s): Sleep scoring results from simultaneously acquired electroencephalography data on Night 2 indicate that subjects (n = 12) reached the full spectrum of sleep stages including slow-wave (M = 52.1 min, SD = 26.5 min) and rapid eye movement (REM, M = 45.2 min, SD = 27.9 min) sleep and exhibited a mean of 2.1 (SD = 1.1) nonREM-REM sleep cycles. Conclusions: It was found that by diligently applying fundamental principles and methodologies of sleep and neuroimaging science, performing all-night fMRI sleep studies is feasible. However, because the two nights of the study were performed consecutively, some sleep deprivation from Night 1 as a cause of the Night 2 results is likely, so consideration should be given to replicating the current study with a washout period. It is envisioned that other laboratories can adopt the core features of this protocol to obtain similar results.",
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Moehlman, TM, de Zwart, JA, Chappel-Farley, MG, Liu, X, McClain, IB, Chang, C, Mandelkow, H, Özbay, PS, Johnson, NL, Bieber, RE, Fernandez, KA, King, KA, Zalewski, CK, Brewer, CC, van Gelderen, P, Duyn, JH & Picchioni, D 2019, 'All-night functional magnetic resonance imaging sleep studies', Journal of Neuroscience Methods, vol. 316, pp. 83-98. https://doi.org/10.1016/j.jneumeth.2018.09.019

All-night functional magnetic resonance imaging sleep studies. / Moehlman, Thomas M.; de Zwart, Jacco A.; Chappel-Farley, Miranda G.; Liu, Xiao; McClain, Irene B.; Chang, Catie; Mandelkow, Hendrik; Özbay, Pinar S.; Johnson, Nicholas L.; Bieber, Rebecca E.; Fernandez, Katharine A.; King, Kelly A.; Zalewski, Christopher K.; Brewer, Carmen C.; van Gelderen, Peter; Duyn, Jeff H.; Picchioni, Dante.

In: Journal of Neuroscience Methods, Vol. 316, 15.03.2019, p. 83-98.

Research output: Contribution to journalArticle

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T1 - All-night functional magnetic resonance imaging sleep studies

AU - Moehlman, Thomas M.

AU - de Zwart, Jacco A.

AU - Chappel-Farley, Miranda G.

AU - Liu, Xiao

AU - McClain, Irene B.

AU - Chang, Catie

AU - Mandelkow, Hendrik

AU - Özbay, Pinar S.

AU - Johnson, Nicholas L.

AU - Bieber, Rebecca E.

AU - Fernandez, Katharine A.

AU - King, Kelly A.

AU - Zalewski, Christopher K.

AU - Brewer, Carmen C.

AU - van Gelderen, Peter

AU - Duyn, Jeff H.

AU - Picchioni, Dante

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Background: Previous functional magnetic resonance imaging (fMRI) sleep studies have been hampered by the difficulty of obtaining extended amounts of sleep in the sleep-adverse environment of the scanner and often have resorted to manipulations such as sleep depriving subjects before scanning. These manipulations limit the generalizability of the results. New method: The current study is a methodological validation of procedures aimed at obtaining all-night fMRI data in sleeping subjects with minimal exposure to experimentally induced sleep deprivation. Specifically, subjects slept in the scanner on two consecutive nights, allowing the first night to serve as an adaptation night. Results/comparison with existing method(s): Sleep scoring results from simultaneously acquired electroencephalography data on Night 2 indicate that subjects (n = 12) reached the full spectrum of sleep stages including slow-wave (M = 52.1 min, SD = 26.5 min) and rapid eye movement (REM, M = 45.2 min, SD = 27.9 min) sleep and exhibited a mean of 2.1 (SD = 1.1) nonREM-REM sleep cycles. Conclusions: It was found that by diligently applying fundamental principles and methodologies of sleep and neuroimaging science, performing all-night fMRI sleep studies is feasible. However, because the two nights of the study were performed consecutively, some sleep deprivation from Night 1 as a cause of the Night 2 results is likely, so consideration should be given to replicating the current study with a washout period. It is envisioned that other laboratories can adopt the core features of this protocol to obtain similar results.

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Moehlman TM, de Zwart JA, Chappel-Farley MG, Liu X, McClain IB, Chang C et al. All-night functional magnetic resonance imaging sleep studies. Journal of Neuroscience Methods. 2019 Mar 15;316:83-98. https://doi.org/10.1016/j.jneumeth.2018.09.019