Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation

Christopher C. Kemball, Eva Szomolanyi-Tsuda, Aron E. Lukacher

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

CD4+ T-cell help enables antiviral CD8+ T cells to differentiate into fully competent memory cells and sustains CD8+ T-cell-mediated immunity during persistent virus infection. We recently reported that mice of C57BL/6 and C3H strains differ in their dependence on CD28 and CD40L costimulation for long-term control of infection by polyoma virus, a persistent mouse pathogen. In this study, we asked whether mice of these inbred strains also vary in their requirement for CD4+ T-cell help for generating and maintaining polyoma virus-specific CD8+ T cells. CD4+ T-cell-depleted C57BL/6 mice mounted a robust antiviral CD8 + T-cell response during acute infection, whereas unhelped CD8 + T-cell effectors in C3H mice were functionally impaired during acute infection and failed to expand upon antigenic challenge during persistent infection. Using (C57BL/6 x C3H)F1 mice, we found that the dispensability for CD4+ T-cell help for the H-2b- restricted polyoma virus-specific CD8+ T-cell response during acute infection extends to the H-2k-restricted antiviral CD8+ T cells. Our findings demonstrate that dependence on CD4+ T-cell help for antiviral CD8+ T-cell effector differentiation can vary among allogeneic strains of inbred mice.

Original languageEnglish (US)
Pages (from-to)13743-13753
Number of pages11
JournalJournal of virology
Volume81
Issue number24
DOIs
StatePublished - Dec 1 2007

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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