Allograft survival in patients receiving anticonvulsant medications

Steven Wassner, M. H. Malekzadeh, A. J. Pennisi, R. B. Ettenger, C. H. Uittenbogaart, R. N. Fine

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The use of phenobarbital and diphenylhydantoin in transplant recipients is associated with reduced cadaver allograft survival when compared to transplant recipients not receiving anticonvulsant medication. An attempt was made to overcome the adverse effect on allograft survival by either discontinuing the anticonvulsants (2 patients) or maintaining the dose of prednisone at >1 mg/kg/day (2 patients). Discontinuation of phenobarbital was successful after transplantation, with subsequent stabilization of allograft function. Of the 2 patients receiving >1 mg/kg/day of prednisone, renal function is normal in 1 patient; however, the second is undergoing chronic rejection. Neither patient appears cushingoid. Anticonvulsant medication should be discontinued prior to transplantation. If the patient has an active seizure disorder, prednisone dosage should be maintained at a higher level.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalClinical Nephrology
Volume8
Issue number1
StatePublished - Dec 1 1977

All Science Journal Classification (ASJC) codes

  • Nephrology

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