Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors

C. Hardt, K. Pfizenmaier, M. Röllinghoff, J. Klein, H. Wagner

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Abstract

If the collaborative requirement of Lyt 1 T helper cells is bypassed by the Lyt 1 T cell-derived mediator of T help, termed I1-2, upon antigenic stimulation, PNA+ Lyt 123 thymocytes differentiate into either alloreactive or H-2-restricted PNA- Lyt 23 cytotoxic effector cells. Along the differentiation pathway from Lyt 123 → 23 effector cells, cytolytic activity is carried out by T cells that still express the Lyt 123 phenotype. The data establish that Lyt 23 CTL are produced by differentiation from antecedent Lyt 123 cells.

Original languageEnglish (US)
Pages (from-to)1413-1418
Number of pages6
JournalJournal of Experimental Medicine
Volume152
Issue number5
DOIs
Publication statusPublished - Dec 1 1980

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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