Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice

Boe Hyun Kim, Yong Chul Jun, Jae Kwang Jin, Jae Il Kim, Nam Ho Kim, Elizabeth A. Leibold, James Connor, Eun Kyoung Choi, Richard I. Carp, Yong Sun Kim

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Abstract

Considerable evidence suggests that oxidative stress may be involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). To investigate the involvement of iron metabolism in TSEs, we examined the expression levels of iron regulatory proteins (IRPs), ferritins, and binding activities of IRPs to iron-responsive element (IRE) in scrapie-infected mice. We found that the IRPs-IRE-binding activities and ferritins were increased in the astrocytes of hippocampus and cerebral cortex in the brains of scrapie-infected mice. These results suggest that alteration of iron metabolism contributes to development of neurodegeneration and that some protective mechanisms against iron-induced oxidative damage may occur during the pathogenesis of TSEs.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalNeuroscience letters
Volume422
Issue number3
DOIs
StatePublished - Jul 18 2007

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kim, B. H., Jun, Y. C., Jin, J. K., Kim, J. I., Kim, N. H., Leibold, E. A., Connor, J., Choi, E. K., Carp, R. I., & Kim, Y. S. (2007). Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. Neuroscience letters, 422(3), 158-163. https://doi.org/10.1016/j.neulet.2007.05.061