Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice

Boe Hyun Kim, Yong Chul Jun, Jae Kwang Jin, Jae Il Kim, Nam Ho Kim, Elizabeth A. Leibold, James Connor, Eun Kyoung Choi, Richard I. Carp, Yong Sun Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Considerable evidence suggests that oxidative stress may be involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). To investigate the involvement of iron metabolism in TSEs, we examined the expression levels of iron regulatory proteins (IRPs), ferritins, and binding activities of IRPs to iron-responsive element (IRE) in scrapie-infected mice. We found that the IRPs-IRE-binding activities and ferritins were increased in the astrocytes of hippocampus and cerebral cortex in the brains of scrapie-infected mice. These results suggest that alteration of iron metabolism contributes to development of neurodegeneration and that some protective mechanisms against iron-induced oxidative damage may occur during the pathogenesis of TSEs.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalNeuroscience letters
Volume422
Issue number3
DOIs
StatePublished - Jul 18 2007

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Iron-Regulatory Proteins
Scrapie
Ferritins
Iron
Prion Diseases
Brain
Protein Binding
Astrocytes
Cerebral Cortex
Hippocampus
Oxidative Stress

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kim, B. H., Jun, Y. C., Jin, J. K., Kim, J. I., Kim, N. H., Leibold, E. A., ... Kim, Y. S. (2007). Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. Neuroscience letters, 422(3), 158-163. https://doi.org/10.1016/j.neulet.2007.05.061
Kim, Boe Hyun ; Jun, Yong Chul ; Jin, Jae Kwang ; Kim, Jae Il ; Kim, Nam Ho ; Leibold, Elizabeth A. ; Connor, James ; Choi, Eun Kyoung ; Carp, Richard I. ; Kim, Yong Sun. / Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. In: Neuroscience letters. 2007 ; Vol. 422, No. 3. pp. 158-163.
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abstract = "Considerable evidence suggests that oxidative stress may be involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). To investigate the involvement of iron metabolism in TSEs, we examined the expression levels of iron regulatory proteins (IRPs), ferritins, and binding activities of IRPs to iron-responsive element (IRE) in scrapie-infected mice. We found that the IRPs-IRE-binding activities and ferritins were increased in the astrocytes of hippocampus and cerebral cortex in the brains of scrapie-infected mice. These results suggest that alteration of iron metabolism contributes to development of neurodegeneration and that some protective mechanisms against iron-induced oxidative damage may occur during the pathogenesis of TSEs.",
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Kim, BH, Jun, YC, Jin, JK, Kim, JI, Kim, NH, Leibold, EA, Connor, J, Choi, EK, Carp, RI & Kim, YS 2007, 'Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice', Neuroscience letters, vol. 422, no. 3, pp. 158-163. https://doi.org/10.1016/j.neulet.2007.05.061

Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. / Kim, Boe Hyun; Jun, Yong Chul; Jin, Jae Kwang; Kim, Jae Il; Kim, Nam Ho; Leibold, Elizabeth A.; Connor, James; Choi, Eun Kyoung; Carp, Richard I.; Kim, Yong Sun.

In: Neuroscience letters, Vol. 422, No. 3, 18.07.2007, p. 158-163.

Research output: Contribution to journalArticle

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AU - Kim, Boe Hyun

AU - Jun, Yong Chul

AU - Jin, Jae Kwang

AU - Kim, Jae Il

AU - Kim, Nam Ho

AU - Leibold, Elizabeth A.

AU - Connor, James

AU - Choi, Eun Kyoung

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AU - Kim, Yong Sun

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