Alterations in total carcass fat of female rats maintained on fat option diets

R. L. Corwin, H. B. Rice, S. G. Dimitriou

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Abstract

We recently reported that limited access fat option diets increased body adiposity without concomitant increases in total calorie consumption or in body weight in non-food-deprived male rats (1). The present study was designed to investigate the effect of these diets on body weight and body fat in female rats. Forty female Sprague-Dawley rats, were individually housed, matched for body weight, and divided into 4 groups. All groups had 24-hour access to chow (Laboratory Rodent Diet 5001, PMI Feeds, Inc., Richmond, IN) and tap water. In addition to the chow, Group A. was given no fat. Group B was given 2-hour access to fat (Crisco brand all vegetable shortening, Procter and Gamble, Cincinnati, OH) on M, W, and F, Group C was given 2-hour access to fat every day, and Group D was given 24-hour access to fat every day. At 8 weeks, all rats were sacrificed, and carcasses were later homogenized for body composition analysis. Total fat intake increased significantly with increasing availability of fat in a dose response manner (p<0.001). Neither body weights nor total calories consumed differed between groups. Total carcass fat was higher in Groups C and D, compared to Group A (p<0.001). Furthermore, total carcass fat in Groups C and D did not differ from each other even though total fat intakes did significantly differ between these two groups (p<0.001). These results show that fat option diets can induce increases in body adiposity that are independent of body weight or total calorie consumption in non-food-deprived female rats. 1) Rice, et al. (1995) Obesity Research 3: 372s.

Original languageEnglish (US)
Pages (from-to)A560
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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