Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults

Autumn Kujawa, Minjie Wu, Heide Klumpp, Daniel S. Pine, James E. Swain, Kate D. Fitzgerald, Christopher S. Monk, K. Luan Phan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background Development of corticoamygdala circuitry underlies the maturation of emotion processing and regulation, and age-related changes in amygdala connectivity with anterior cingulate cortex (ACC) have been shown to mediate normative developmental decreases in anxiety. It remains unclear whether developmental changes in this circuitry relate to pathological anxiety in youth. The current functional magnetic resonance imaging study addresses this question by examining amygdala functional connectivity in anxious and healthy individuals spanning the developmental period from childhood through adulthood. Methods Youth and young adults (ages 7-25) with current anxiety disorders (n = 57) and healthy comparison subjects (n = 61) completed a functional magnetic resonance imaging emotional face processing task known to elicit amygdala activation in youth and adults. We examined interaction effects of anxiety group and age on amygdala connectivity with frontolimbic regions during processing of happy, angry, and fearful faces. Results Anxiety interacted with age to predict amygdala-ACC connectivity across emotional faces. Among healthy youth and young adults, age was negatively related to connectivity. In contrast, age was positively associated with amygdala-ACC connectivity in the anxious group. Group effects were also observed on amygdala connectivity with midcingulate and middle frontal gyri. Effects of anxiety and age on amygdala activation were not significant. Conclusions Results indicate that anxiety is characterized by altered patterns of age-related changes in amygdala connectivity during emotional face processing. Positive associations between age and amygdala-ACC connectivity among anxious youth and young adults may indicate failure to establish early bottom-up connections in childhood and/or less top-down regulation of the amygdala into adulthood.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume1
Issue number4
DOIs
StatePublished - Jul 1 2016

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Gyrus Cinguli
Amygdala
Young Adult
Anxiety
Magnetic Resonance Imaging
Anxiety Disorders
Healthy Volunteers
Emotions
Down-Regulation
Age Groups

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Clinical Neurology
  • Biological Psychiatry

Cite this

Kujawa, Autumn ; Wu, Minjie ; Klumpp, Heide ; Pine, Daniel S. ; Swain, James E. ; Fitzgerald, Kate D. ; Monk, Christopher S. ; Phan, K. Luan. / Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults. In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2016 ; Vol. 1, No. 4. pp. 345-352.
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abstract = "Background Development of corticoamygdala circuitry underlies the maturation of emotion processing and regulation, and age-related changes in amygdala connectivity with anterior cingulate cortex (ACC) have been shown to mediate normative developmental decreases in anxiety. It remains unclear whether developmental changes in this circuitry relate to pathological anxiety in youth. The current functional magnetic resonance imaging study addresses this question by examining amygdala functional connectivity in anxious and healthy individuals spanning the developmental period from childhood through adulthood. Methods Youth and young adults (ages 7-25) with current anxiety disorders (n = 57) and healthy comparison subjects (n = 61) completed a functional magnetic resonance imaging emotional face processing task known to elicit amygdala activation in youth and adults. We examined interaction effects of anxiety group and age on amygdala connectivity with frontolimbic regions during processing of happy, angry, and fearful faces. Results Anxiety interacted with age to predict amygdala-ACC connectivity across emotional faces. Among healthy youth and young adults, age was negatively related to connectivity. In contrast, age was positively associated with amygdala-ACC connectivity in the anxious group. Group effects were also observed on amygdala connectivity with midcingulate and middle frontal gyri. Effects of anxiety and age on amygdala activation were not significant. Conclusions Results indicate that anxiety is characterized by altered patterns of age-related changes in amygdala connectivity during emotional face processing. Positive associations between age and amygdala-ACC connectivity among anxious youth and young adults may indicate failure to establish early bottom-up connections in childhood and/or less top-down regulation of the amygdala into adulthood.",
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Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults. / Kujawa, Autumn; Wu, Minjie; Klumpp, Heide; Pine, Daniel S.; Swain, James E.; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. Luan.

In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 1, No. 4, 01.07.2016, p. 345-352.

Research output: Contribution to journalArticle

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T1 - Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults

AU - Kujawa, Autumn

AU - Wu, Minjie

AU - Klumpp, Heide

AU - Pine, Daniel S.

AU - Swain, James E.

AU - Fitzgerald, Kate D.

AU - Monk, Christopher S.

AU - Phan, K. Luan

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Y1 - 2016/7/1

N2 - Background Development of corticoamygdala circuitry underlies the maturation of emotion processing and regulation, and age-related changes in amygdala connectivity with anterior cingulate cortex (ACC) have been shown to mediate normative developmental decreases in anxiety. It remains unclear whether developmental changes in this circuitry relate to pathological anxiety in youth. The current functional magnetic resonance imaging study addresses this question by examining amygdala functional connectivity in anxious and healthy individuals spanning the developmental period from childhood through adulthood. Methods Youth and young adults (ages 7-25) with current anxiety disorders (n = 57) and healthy comparison subjects (n = 61) completed a functional magnetic resonance imaging emotional face processing task known to elicit amygdala activation in youth and adults. We examined interaction effects of anxiety group and age on amygdala connectivity with frontolimbic regions during processing of happy, angry, and fearful faces. Results Anxiety interacted with age to predict amygdala-ACC connectivity across emotional faces. Among healthy youth and young adults, age was negatively related to connectivity. In contrast, age was positively associated with amygdala-ACC connectivity in the anxious group. Group effects were also observed on amygdala connectivity with midcingulate and middle frontal gyri. Effects of anxiety and age on amygdala activation were not significant. Conclusions Results indicate that anxiety is characterized by altered patterns of age-related changes in amygdala connectivity during emotional face processing. Positive associations between age and amygdala-ACC connectivity among anxious youth and young adults may indicate failure to establish early bottom-up connections in childhood and/or less top-down regulation of the amygdala into adulthood.

AB - Background Development of corticoamygdala circuitry underlies the maturation of emotion processing and regulation, and age-related changes in amygdala connectivity with anterior cingulate cortex (ACC) have been shown to mediate normative developmental decreases in anxiety. It remains unclear whether developmental changes in this circuitry relate to pathological anxiety in youth. The current functional magnetic resonance imaging study addresses this question by examining amygdala functional connectivity in anxious and healthy individuals spanning the developmental period from childhood through adulthood. Methods Youth and young adults (ages 7-25) with current anxiety disorders (n = 57) and healthy comparison subjects (n = 61) completed a functional magnetic resonance imaging emotional face processing task known to elicit amygdala activation in youth and adults. We examined interaction effects of anxiety group and age on amygdala connectivity with frontolimbic regions during processing of happy, angry, and fearful faces. Results Anxiety interacted with age to predict amygdala-ACC connectivity across emotional faces. Among healthy youth and young adults, age was negatively related to connectivity. In contrast, age was positively associated with amygdala-ACC connectivity in the anxious group. Group effects were also observed on amygdala connectivity with midcingulate and middle frontal gyri. Effects of anxiety and age on amygdala activation were not significant. Conclusions Results indicate that anxiety is characterized by altered patterns of age-related changes in amygdala connectivity during emotional face processing. Positive associations between age and amygdala-ACC connectivity among anxious youth and young adults may indicate failure to establish early bottom-up connections in childhood and/or less top-down regulation of the amygdala into adulthood.

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