Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention

Yi Zhang, Jin-Ming Yang

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalCancer Biology and Therapy
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2013

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Energy Metabolism
Neoplasms
Therapeutics
Glycolysis
Metabolic Networks and Pathways
Glutamine
Mitochondria
Growth

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Cite this

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Altered energy metabolism in cancer : A unique opportunity for therapeutic intervention. / Zhang, Yi; Yang, Jin-Ming.

In: Cancer Biology and Therapy, Vol. 14, No. 2, 01.02.2013, p. 81-89.

Research output: Contribution to journalReview article

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