Abstract
Human exposure to cold stimulates cutaneous vasoconstriction by activating both sympathetic reflex and locally mediated pathways. Older humans are vulnerable to hypothermia because primary aging impairs thermoregulatory cutaneous vasoconstriction. This article highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairment, whereas changes in local cold-induced intracellular signaling suggest a more generalized age-associated vascular dysfunction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 122-127 |
| Number of pages | 6 |
| Journal | Exercise and Sport Sciences Reviews |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2008 |
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All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
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Altered mechanisms of thermoregulatory vasoconstriction in aged human skin. / Thompson-Torgerson, Caitlin S.; Alexander, Lacy Marie; Kenney, Jr., William Lawrence.
In: Exercise and Sport Sciences Reviews, Vol. 36, No. 3, 01.07.2008, p. 122-127.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Altered mechanisms of thermoregulatory vasoconstriction in aged human skin
AU - Thompson-Torgerson, Caitlin S.
AU - Alexander, Lacy Marie
AU - Kenney, Jr., William Lawrence
PY - 2008/7/1
Y1 - 2008/7/1
N2 - Human exposure to cold stimulates cutaneous vasoconstriction by activating both sympathetic reflex and locally mediated pathways. Older humans are vulnerable to hypothermia because primary aging impairs thermoregulatory cutaneous vasoconstriction. This article highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairment, whereas changes in local cold-induced intracellular signaling suggest a more generalized age-associated vascular dysfunction.
AB - Human exposure to cold stimulates cutaneous vasoconstriction by activating both sympathetic reflex and locally mediated pathways. Older humans are vulnerable to hypothermia because primary aging impairs thermoregulatory cutaneous vasoconstriction. This article highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairment, whereas changes in local cold-induced intracellular signaling suggest a more generalized age-associated vascular dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=50349086202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50349086202&partnerID=8YFLogxK
U2 - 10.1097/JES.0b013e31817bfd47
DO - 10.1097/JES.0b013e31817bfd47
M3 - Review article
C2 - 18580292
AN - SCOPUS:50349086202
VL - 36
SP - 122
EP - 127
JO - Exercise and Sport Sciences Reviews
JF - Exercise and Sport Sciences Reviews
SN - 0091-6331
IS - 3
ER -