Altered monamine metabolism in caudate-putamen of iron-deficient rats

John L. Beard, Qing Chen, James Connor, Byron C. Jones

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The effect of iron deficiency on brain monoamine metabolism using in vivo microdialysis techniques has not been previously reported. We, therefore, examined the monoamines, dopamine and norepinephrine, and their metabolites at steady state by in vivo microdialysis in rat brain caudate-putamen in 11-week-old iron-deficient anemic (hemoglobin < 7 g/dl) and control rats (Hb > 14 g/dl). Caudate-putamen dopamine (DA), dihydroxyphenyl acetic acid (DOPAC), and homovanillic acid (HVA) concentrations were increased by 53%, 57%, and 30% (p < 0.001), respectively, in iron-deficient rats in samples collected over a 4-h period. While diminished numbers of D2 receptors have been previously reported, the present findings suggest an additional defect in monoamine uptake and catabolism.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume48
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Putamen
Metabolism
Rats
Iron
Microdialysis
Dopamine
Brain
Homovanillic Acid
Metabolites
Acetic Acid
Norepinephrine
Hemoglobins
Defects

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Beard, John L. ; Chen, Qing ; Connor, James ; Jones, Byron C. / Altered monamine metabolism in caudate-putamen of iron-deficient rats. In: Pharmacology, Biochemistry and Behavior. 1994 ; Vol. 48, No. 3. pp. 621-624.
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Altered monamine metabolism in caudate-putamen of iron-deficient rats. / Beard, John L.; Chen, Qing; Connor, James; Jones, Byron C.

In: Pharmacology, Biochemistry and Behavior, Vol. 48, No. 3, 01.01.1994, p. 621-624.

Research output: Contribution to journalArticle

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