Alternating block polyurethanes based on PCL and PEG as potential nerve regeneration materials

Guangyao Li, Dandan Li, Yuqing Niu, Tao He, Kevin C. Chen, Kaitian Xu

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Polyurethanes with regular and controlled block arrangement, i.e., alternating block polyurethanes (abbreviated as PUCL-alt-PEG) based on poly(ε-caprolactone) (PCL-diol) and poly(ethylene glycol) (PEG) was prepared via selectively coupling reaction between PCL-diol and diisocyanate end-capped PEG. Chemical structure, molecular weight, distribution, and thermal properties were systematically characterized by FTIR, 1H NMR, GPC, DSC, and TGA. Hydrophilicity was studied by static contact angle of H 2O and CH2I2. Film surface was observed by scanning electron microscope (SEM) and atomic force microscopy, and mechanical properties were assessed by universal test machine. Results show that alternating block polyurethanes give higher crystal degree, higher mechanical properties, and more hydrophilic and rougher (deep ravine) surface than their random counterpart, due to regular and controlled structure. Platelet adhesion illustrated that PUCL-alt-PEG has better hemocompatibility and the hemacompatibility was affected significantly by PEG content. Excellent hemocompatibility was obtained with high PEG content. CCK-8 assay and SEM observation revealed much better cell compatibility of fibroblast L929 and rat glial cells on the alternating block polyurethanes than that on random counterpart. Alternating block polyurethane PUC20-a-E4 with optimized composition, mechanical, surface properties, hemacompatibility, and highest cell growth and proliferation was achieved for potential use in nerve regeneration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 685-697, 2014.

Original languageEnglish (US)
Pages (from-to)685-697
Number of pages13
JournalJournal of Biomedical Materials Research - Part A
Volume102
Issue number3
DOIs
StatePublished - Mar 1 2014

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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