TY - JOUR
T1 - Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating
AU - Casey, Jonathan S.
AU - Arrizabalaga, Julien H.
AU - Abu-Laban, Mohammad
AU - Becca, Jeffrey C.
AU - Rose, Benjamin J.
AU - Strickland, Kevin T.
AU - Bursavich, Jacob B.
AU - McCann, Jacob S.
AU - Pacheco, Carlos N.
AU - Jessen, Lasse
AU - Attaluri, Anilchandra
AU - Hayes, Daniel J.
N1 - Funding Information:
This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program under Award No. W81XWH-18-1-0115. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense . Dr. Hayes, Dr. Laban and Jonathan Casey acknowledge support from the National Institute of Dental and Craniofacial Research of the National Institutes of Health under award number RDE024790A . Dr. Lasse Jessen and Jeffrey Becca acknowledge support from NSF Award Nos. CHE-1362825 and NRT-1449785 . The authors of this study are grateful to Dr. Alfonso Davila for consultation regarding the linkage chemistry to the nanoparticles; Jennifer Grey for assistance with TEM imaging. The authors would like to thank Dr. Tatiana Laremore and Dr. Hua Tian for their assistance with mass spectrometry analysis, Laura Linney for ICP -OES analysis, and Ryan Hoff for assisting with the nanoparticle synthesis. The authors would like to thank Nichole Wonderling and Gino Tambourine for their assistance with powder X-ray diffraction.
Funding Information:
This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program under Award No. W81XWH-18-1-0115. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. Dr. Hayes, Dr. Laban and Jonathan Casey acknowledge support from the National Institute of Dental and Craniofacial Research of the National Institutes of Health under award number RDE024790A. Dr. Lasse Jessen and Jeffrey Becca acknowledge support from NSF Award Nos. CHE-1362825 and NRT-1449785. The authors of this study are grateful to Dr. Alfonso Davila for consultation regarding the linkage chemistry to the nanoparticles; Jennifer Grey for assistance with TEM imaging. The authors would like to thank Dr. Tatiana Laremore and Dr. Hua Tian for their assistance with mass spectrometry analysis, Laura Linney for ICP-OES analysis, and Ryan Hoff for assisting with the nanoparticle synthesis. The authors would like to thank Nichole Wonderling and Gino Tambourine for their assistance with powder X-ray diffraction.
Publisher Copyright:
© 2020
PY - 2020/7/1
Y1 - 2020/7/1
N2 - This study explores the use of differential heating of magnetic nanoparticles with different sizes and compositions (MFe2O4 (M = Fe, Co)) for heteroplexed temporal controlled release of conjugated fluorophores from the surface of nanoparticles. By exploiting these differences, we were able to control the amount of hysteretic heating occurring with the distinct sets of magnetic nanoparticles using the same applied alternating magnetic field radio frequency (AMF-RF). Using thermally labile retro-Diels-Alder linkers conjugated to the surface of nanoparticles, the fluorescent payload from the different nanoparticles disengaged when sufficient energy was locally generated during hysteretic heating. 1H, 13C NMR, ESI-MS, and SIMS characterized the thermally responsive fluorescent cycloadducts used in this study; the Diels Alder cycloadducts were modeled using density functional theory (DFT) computations. The localized point heating of the different nanoparticle compositions drove the retro-Diels-Alder reaction at different times resulting in higher release rates of fluorophores from the CoFe2O4 compared to the Fe3O4 nanoparticles.
AB - This study explores the use of differential heating of magnetic nanoparticles with different sizes and compositions (MFe2O4 (M = Fe, Co)) for heteroplexed temporal controlled release of conjugated fluorophores from the surface of nanoparticles. By exploiting these differences, we were able to control the amount of hysteretic heating occurring with the distinct sets of magnetic nanoparticles using the same applied alternating magnetic field radio frequency (AMF-RF). Using thermally labile retro-Diels-Alder linkers conjugated to the surface of nanoparticles, the fluorescent payload from the different nanoparticles disengaged when sufficient energy was locally generated during hysteretic heating. 1H, 13C NMR, ESI-MS, and SIMS characterized the thermally responsive fluorescent cycloadducts used in this study; the Diels Alder cycloadducts were modeled using density functional theory (DFT) computations. The localized point heating of the different nanoparticle compositions drove the retro-Diels-Alder reaction at different times resulting in higher release rates of fluorophores from the CoFe2O4 compared to the Fe3O4 nanoparticles.
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U2 - 10.1016/j.jcis.2020.03.056
DO - 10.1016/j.jcis.2020.03.056
M3 - Article
C2 - 32209489
AN - SCOPUS:85082011294
VL - 571
SP - 348
EP - 355
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
ER -