Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)

Jueyu Pan, Guangyao Li, Zhifei Chen, Xianyu Chen, Wenfu Zhu, Kaitian Xu

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

A series of amphiphilic alternative block polyurethane copolymers based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3/4HB) and poly(ethylene glycol) (PEG) were synthesized by a coupling reaction between P3/4HB-diol and PEG-diisocyanate, with different 3HB, 4HB, PEG compositions and segment lengths. Stannous octanoate was used as catalyst. The chemical structure, alternative block arrangement, molecular weight and distribution were systematically characterized by FTIR, 1H NMR, GPC and composition analysis. The thermal property was studied by DSC and TGA. Platelet adhesion study revealed that the alternative block polyurethanes possess excellent hemocompatibility. CCK-8 assay illuminated that the non-toxic block polyurethanes maintain rat aortic smooth muscle cells (RaSMCs) good viability. The in-vitro degradation of the copolymers in PBS buffer solution and in lipase buffer medium was investigated. Results showed that the copolymer films exhibit different degradation patterns in different media from surface erosion to diffusion bulk collapsing. The synthetic methodology for the alternative block polyurethanes provides a way to control the exact structure of the biomaterials and tailor the properties to subtle requirements.

Original languageEnglish (US)
Pages (from-to)2975-2984
Number of pages10
JournalBiomaterials
Volume30
Issue number16
DOIs
StatePublished - Jun 1 2009

Fingerprint

Polyurethanes
Ethylene Glycol
Polyethylene glycols
Copolymers
Buffers
Degradation
Sincalide
Lipases
Biocompatible Materials
Fourier Transform Infrared Spectroscopy
Platelets
Lipase
Chemical analysis
Biomaterials
Smooth Muscle Myocytes
Muscle
Rats
Erosion
Assays
Cell Survival

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Pan, Jueyu ; Li, Guangyao ; Chen, Zhifei ; Chen, Xianyu ; Zhu, Wenfu ; Xu, Kaitian. / Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol). In: Biomaterials. 2009 ; Vol. 30, No. 16. pp. 2975-2984.
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Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol). / Pan, Jueyu; Li, Guangyao; Chen, Zhifei; Chen, Xianyu; Zhu, Wenfu; Xu, Kaitian.

In: Biomaterials, Vol. 30, No. 16, 01.06.2009, p. 2975-2984.

Research output: Contribution to journalArticle

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