Amantadine for adynamic speech

Possible benefit for aphasia?

Anna M. Barrett, Paul Eslinger

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

OBJECTIVE: Dopaminergic agents may stimulate behavior and verbal expression after frontal lobe dysfunction. Although amantadine is used in neurorehabilitation of motivational disorders and head injury, it is not commonly prescribed to improve aphasia. This pilot study examined verbal fluency on and off amantadine for nonfluent speech. DESIGN: Four participants undergoing inpatient rehabilitation, meeting criteria for transcortical motor aphasia had stroke (2), stroke postaneurysm surgery (1), or brain tumor resection (1). We administered 100 mg of amantadine twice a day in an open-label, on-off protocol, with multiple assessments per on-off period. RESULTS: Off medication, subjects generated a mean 12.62 of words (abnormally few) on the Controlled Oral Word Association test. On medication, word generation significantly improved to 17.71 words (P = 0.04), although scores remained psychometrically in the abnormal range. CONCLUSIONS: Further research on amantadine, specifically for nonfluent speech and nonfluent aphasia, including effects on functional communication and control conditions, may be warranted.

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume86
Issue number8
DOIs
StatePublished - Sep 1 2007

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Amantadine
Aphasia
Broca Aphasia
Word Association Tests
Stroke
Verbal Behavior
Dopamine Agents
Frontal Lobe
Craniocerebral Trauma
Brain Neoplasms
Inpatients
Rehabilitation
Communication
Research

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Cite this

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Amantadine for adynamic speech : Possible benefit for aphasia? / Barrett, Anna M.; Eslinger, Paul.

In: American Journal of Physical Medicine and Rehabilitation, Vol. 86, No. 8, 01.09.2007, p. 605-612.

Research output: Contribution to journalArticle

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