Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries

Hualiang Lin, Yanfei Guo, Zengliang Ruan, Yin Yang, Yanbing Chen, Yang Zheng, Lenise A. Cummings-Vaughn, Steven E. Rigdon, Michael G. Vaughn, Shengzhi Sun, Lingli Zhang, Xiaojie Wang, Zhengmin Qian, Fan Wu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Ambient air pollutant directly contacts with the eyes, however, the effect of ambient fine particulate matter (PM2.5) and ozone (O3) on vision impairment, such as presbyopia, has been kept largely unknown. Methods: We surveyed a total of 36,620 participants aged 50 years and above in six low- and middle-income countries. Ambient annual concentrations of PM2.5 and O3 for the residential community were estimated using satellite data and chemical transport model. A mixed effects model was utilized to assess the effects of ambient PM2.5 and O3 on presbyopia, as well as their combined effects. Results: A total of 13,841 presbyopia cases were identified among the participants with a prevalence rate of 41.17%. For both PM2.5 and O3, we found a J-shaped exposure-response relationship with the threshold being identified at 15 μg/m3 for PM2.5 and 55 μg/m3 for O3. The odds ratio (OR) of presbyopia was 1.15 (95% CI: 1.09, 1.21) for each 10 μg/m3 increase in PM2.5 above 15 μg/m3 and 1.37 (95% CI: 1.23, 1.54) for O3 above 55 μg/m3 after adjusting for various potential confounding factors. There appeared to be a synergistic interaction between ambient PM2.5 and O3 on presbyopia in the additive model, the combined effect was significantly larger than the sum of their individual effects, with a synergistic index of 2.39. Conclusion: This study supports that exposures to ambient PM2.5 and O3 might be important risk factors of presbyopia among old adults, and simultaneously exposure to high level of the two pollutants could intensify their individual effects.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalScience of the Total Environment
Volume655
DOIs
StatePublished - Mar 10 2019

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income
Air Pollutants
Particulate Matter
Ozone
Contacts (fluid mechanics)
Satellites
Air
effect
risk factor
ambient air
particulate matter
satellite data
ozone
pollutant
exposure

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Lin, Hualiang ; Guo, Yanfei ; Ruan, Zengliang ; Yang, Yin ; Chen, Yanbing ; Zheng, Yang ; Cummings-Vaughn, Lenise A. ; Rigdon, Steven E. ; Vaughn, Michael G. ; Sun, Shengzhi ; Zhang, Lingli ; Wang, Xiaojie ; Qian, Zhengmin ; Wu, Fan. / Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly : A cross-sectional study in six low- and middle-income countries. In: Science of the Total Environment. 2019 ; Vol. 655. pp. 168-173.
@article{06cf8a7c1b4845f0ae448bfb0690bc4c,
title = "Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries",
abstract = "Background: Ambient air pollutant directly contacts with the eyes, however, the effect of ambient fine particulate matter (PM2.5) and ozone (O3) on vision impairment, such as presbyopia, has been kept largely unknown. Methods: We surveyed a total of 36,620 participants aged 50 years and above in six low- and middle-income countries. Ambient annual concentrations of PM2.5 and O3 for the residential community were estimated using satellite data and chemical transport model. A mixed effects model was utilized to assess the effects of ambient PM2.5 and O3 on presbyopia, as well as their combined effects. Results: A total of 13,841 presbyopia cases were identified among the participants with a prevalence rate of 41.17{\%}. For both PM2.5 and O3, we found a J-shaped exposure-response relationship with the threshold being identified at 15 μg/m3 for PM2.5 and 55 μg/m3 for O3. The odds ratio (OR) of presbyopia was 1.15 (95{\%} CI: 1.09, 1.21) for each 10 μg/m3 increase in PM2.5 above 15 μg/m3 and 1.37 (95{\%} CI: 1.23, 1.54) for O3 above 55 μg/m3 after adjusting for various potential confounding factors. There appeared to be a synergistic interaction between ambient PM2.5 and O3 on presbyopia in the additive model, the combined effect was significantly larger than the sum of their individual effects, with a synergistic index of 2.39. Conclusion: This study supports that exposures to ambient PM2.5 and O3 might be important risk factors of presbyopia among old adults, and simultaneously exposure to high level of the two pollutants could intensify their individual effects.",
author = "Hualiang Lin and Yanfei Guo and Zengliang Ruan and Yin Yang and Yanbing Chen and Yang Zheng and Cummings-Vaughn, {Lenise A.} and Rigdon, {Steven E.} and Vaughn, {Michael G.} and Shengzhi Sun and Lingli Zhang and Xiaojie Wang and Zhengmin Qian and Fan Wu",
year = "2019",
month = "3",
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doi = "10.1016/j.scitotenv.2018.11.239",
language = "English (US)",
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Lin, H, Guo, Y, Ruan, Z, Yang, Y, Chen, Y, Zheng, Y, Cummings-Vaughn, LA, Rigdon, SE, Vaughn, MG, Sun, S, Zhang, L, Wang, X, Qian, Z & Wu, F 2019, 'Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries', Science of the Total Environment, vol. 655, pp. 168-173. https://doi.org/10.1016/j.scitotenv.2018.11.239

Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly : A cross-sectional study in six low- and middle-income countries. / Lin, Hualiang; Guo, Yanfei; Ruan, Zengliang; Yang, Yin; Chen, Yanbing; Zheng, Yang; Cummings-Vaughn, Lenise A.; Rigdon, Steven E.; Vaughn, Michael G.; Sun, Shengzhi; Zhang, Lingli; Wang, Xiaojie; Qian, Zhengmin; Wu, Fan.

In: Science of the Total Environment, Vol. 655, 10.03.2019, p. 168-173.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly

T2 - A cross-sectional study in six low- and middle-income countries

AU - Lin, Hualiang

AU - Guo, Yanfei

AU - Ruan, Zengliang

AU - Yang, Yin

AU - Chen, Yanbing

AU - Zheng, Yang

AU - Cummings-Vaughn, Lenise A.

AU - Rigdon, Steven E.

AU - Vaughn, Michael G.

AU - Sun, Shengzhi

AU - Zhang, Lingli

AU - Wang, Xiaojie

AU - Qian, Zhengmin

AU - Wu, Fan

PY - 2019/3/10

Y1 - 2019/3/10

N2 - Background: Ambient air pollutant directly contacts with the eyes, however, the effect of ambient fine particulate matter (PM2.5) and ozone (O3) on vision impairment, such as presbyopia, has been kept largely unknown. Methods: We surveyed a total of 36,620 participants aged 50 years and above in six low- and middle-income countries. Ambient annual concentrations of PM2.5 and O3 for the residential community were estimated using satellite data and chemical transport model. A mixed effects model was utilized to assess the effects of ambient PM2.5 and O3 on presbyopia, as well as their combined effects. Results: A total of 13,841 presbyopia cases were identified among the participants with a prevalence rate of 41.17%. For both PM2.5 and O3, we found a J-shaped exposure-response relationship with the threshold being identified at 15 μg/m3 for PM2.5 and 55 μg/m3 for O3. The odds ratio (OR) of presbyopia was 1.15 (95% CI: 1.09, 1.21) for each 10 μg/m3 increase in PM2.5 above 15 μg/m3 and 1.37 (95% CI: 1.23, 1.54) for O3 above 55 μg/m3 after adjusting for various potential confounding factors. There appeared to be a synergistic interaction between ambient PM2.5 and O3 on presbyopia in the additive model, the combined effect was significantly larger than the sum of their individual effects, with a synergistic index of 2.39. Conclusion: This study supports that exposures to ambient PM2.5 and O3 might be important risk factors of presbyopia among old adults, and simultaneously exposure to high level of the two pollutants could intensify their individual effects.

AB - Background: Ambient air pollutant directly contacts with the eyes, however, the effect of ambient fine particulate matter (PM2.5) and ozone (O3) on vision impairment, such as presbyopia, has been kept largely unknown. Methods: We surveyed a total of 36,620 participants aged 50 years and above in six low- and middle-income countries. Ambient annual concentrations of PM2.5 and O3 for the residential community were estimated using satellite data and chemical transport model. A mixed effects model was utilized to assess the effects of ambient PM2.5 and O3 on presbyopia, as well as their combined effects. Results: A total of 13,841 presbyopia cases were identified among the participants with a prevalence rate of 41.17%. For both PM2.5 and O3, we found a J-shaped exposure-response relationship with the threshold being identified at 15 μg/m3 for PM2.5 and 55 μg/m3 for O3. The odds ratio (OR) of presbyopia was 1.15 (95% CI: 1.09, 1.21) for each 10 μg/m3 increase in PM2.5 above 15 μg/m3 and 1.37 (95% CI: 1.23, 1.54) for O3 above 55 μg/m3 after adjusting for various potential confounding factors. There appeared to be a synergistic interaction between ambient PM2.5 and O3 on presbyopia in the additive model, the combined effect was significantly larger than the sum of their individual effects, with a synergistic index of 2.39. Conclusion: This study supports that exposures to ambient PM2.5 and O3 might be important risk factors of presbyopia among old adults, and simultaneously exposure to high level of the two pollutants could intensify their individual effects.

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DO - 10.1016/j.scitotenv.2018.11.239

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