Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not toxic in single-dose oral and dermal animal tests, and no systemic toxicities were observed in repeat-dose dermal animal studies. In dermal animal studies, no evidence of reproductive or developmental toxicity was reported. At 15% concentrations, sodium dodecylbenzenesulfonate was severely irritating to rabbit skin. The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Products containing these ingredients should be formulated to ensure that the irritancy potential is minimized.

Original languageEnglish (US)
JournalInternational journal of toxicology
Volume29
Issue number6
DOIs
StatePublished - Nov 1 2010

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Cosmetics
Animals
Salts
Safety
Detergents
Skin
Toxicity
Skin Absorption
Irritants
Poisons
Skin Tests
Surface-Active Agents
Alcohols
Rabbits
Water
dodecylbenzenesulfonic acid

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Becker, Lillian C. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. In: International journal of toxicology. 2010 ; Vol. 29, No. 6.
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abstract = "Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not toxic in single-dose oral and dermal animal tests, and no systemic toxicities were observed in repeat-dose dermal animal studies. In dermal animal studies, no evidence of reproductive or developmental toxicity was reported. At 15{\%} concentrations, sodium dodecylbenzenesulfonate was severely irritating to rabbit skin. The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Products containing these ingredients should be formulated to ensure that the irritancy potential is minimized.",
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Becker, LC, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2010, 'Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics', International journal of toxicology, vol. 29, no. 6. https://doi.org/10.1177/1091581810386124

Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. / Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 29, No. 6, 01.11.2010.

Research output: Contribution to journalArticle

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AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

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