Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett, Ivan Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journalArticle

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

Original languageEnglish (US)
Pages (from-to)70S-84S
JournalInternational journal of toxicology
Volume38
Issue number1_suppl
DOIs
StatePublished - May 1 2019

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Cosmetics
Safety
Risk assessment
Animals
2-methyl-4-isothiazolin-3-one

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Burnett, C. L., Boyer, I., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Heldreth, B. (2019). Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. International journal of toxicology, 38(1_suppl), 70S-84S. https://doi.org/10.1177/1091581819838792
Burnett, Christina L. ; Boyer, Ivan ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Gill, Lillian J. ; Heldreth, Bart. / Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. In: International journal of toxicology. 2019 ; Vol. 38, No. 1_suppl. pp. 70S-84S.
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Burnett, CL, Boyer, I, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Gill, LJ & Heldreth, B 2019, 'Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics', International journal of toxicology, vol. 38, no. 1_suppl, pp. 70S-84S. https://doi.org/10.1177/1091581819838792

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. / Burnett, Christina L.; Boyer, Ivan; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart.

In: International journal of toxicology, Vol. 38, No. 1_suppl, 01.05.2019, p. 70S-84S.

Research output: Contribution to journalArticle

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Burnett CL, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. International journal of toxicology. 2019 May 1;38(1_suppl):70S-84S. https://doi.org/10.1177/1091581819838792