Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.

W. S. Liao, R. W. Hamilton, J. M. Taylor

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The nucleotide sequence of the 3'-terminal untranslated region and a portion of the coding region of rat alpha-fetoprotein mRNA has been determined from a cloned double-stranded cDNA. the amino acid sequence of the COOH-terminal portion of alpha-fetoprotein was inferred from the nucleotide sequence and compared to the amino acid sequence of the corresponding portion of rat, bovine, and human albumin. A striking homology in amino acid sequence between alpha-fetoprotein and albumin was observed. These results confirm earlier suggestions that the two proteins are closely related in structure and probably arose from a common ancestral gene.

Original languageEnglish (US)
Pages (from-to)8046-8049
Number of pages4
JournalJournal of Biological Chemistry
Volume255
Issue number17
StatePublished - Sep 10 1980

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.'. Together they form a unique fingerprint.

Cite this