Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.

W. S. Liao, Robert Hamilton, J. M. Taylor

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The nucleotide sequence of the 3'-terminal untranslated region and a portion of the coding region of rat alpha-fetoprotein mRNA has been determined from a cloned double-stranded cDNA. the amino acid sequence of the COOH-terminal portion of alpha-fetoprotein was inferred from the nucleotide sequence and compared to the amino acid sequence of the corresponding portion of rat, bovine, and human albumin. A striking homology in amino acid sequence between alpha-fetoprotein and albumin was observed. These results confirm earlier suggestions that the two proteins are closely related in structure and probably arose from a common ancestral gene.

Original languageEnglish (US)
Pages (from-to)8046-8049
Number of pages4
JournalJournal of Biological Chemistry
Volume255
Issue number17
StatePublished - Sep 10 1980

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Amino Acid Sequence Homology
alpha-Fetoproteins
Amino Acid Sequence
Amino Acids
3' Untranslated Regions
Nucleotides
Untranslated Regions
Albumins
Complementary DNA
Messenger RNA
Rats
Genes
Proteins
alpha-albumin
rat Afp protein

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions. / Liao, W. S.; Hamilton, Robert; Taylor, J. M.

In: Journal of Biological Chemistry, Vol. 255, No. 17, 10.09.1980, p. 8046-8049.

Research output: Contribution to journalArticle

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