Amino acids as regulators of gene expression

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.

Original languageEnglish (US)
JournalNutrition and Metabolism
Volume1
DOIs
StatePublished - Aug 17 2004

Fingerprint

Regulator Genes
Gene Expression
Amino Acids
Protein Biosynthesis
Branched Chain Amino Acids
Somatomedins
Leucine
Signal Transduction
Hormones
Insulin
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

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title = "Amino acids as regulators of gene expression",
abstract = "The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.",
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publisher = "BioMed Central",

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Amino acids as regulators of gene expression. / Kimball, Scot; Jefferson, Leonard "Jim".

In: Nutrition and Metabolism, Vol. 1, 17.08.2004.

Research output: Contribution to journalReview article

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AU - Kimball, Scot

AU - Jefferson, Leonard "Jim"

PY - 2004/8/17

Y1 - 2004/8/17

N2 - The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.

AB - The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.

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