Aminoglutethimide-induced hematologic toxicity: Worldwide experience

A. A. Messeih, Allan Lipton, R. J. Santen, Harold Harvey, A. E. Boucher, R. Murray, J. Ragaz, A. U. Buzdar, G. A. Nagel, I. C. Henderson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

Original languageEnglish (US)
Pages (from-to)1003-1004
Number of pages2
JournalCancer Treatment Reports
Volume69
Issue number9
StatePublished - Dec 11 1985

Fingerprint

Aminoglutethimide
Blood Cell Count
Leukopenia
Thrombocytopenia
Sepsis
Bone Marrow
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Messeih, A. A., Lipton, A., Santen, R. J., Harvey, H., Boucher, A. E., Murray, R., ... Henderson, I. C. (1985). Aminoglutethimide-induced hematologic toxicity: Worldwide experience. Cancer Treatment Reports, 69(9), 1003-1004.
Messeih, A. A. ; Lipton, Allan ; Santen, R. J. ; Harvey, Harold ; Boucher, A. E. ; Murray, R. ; Ragaz, J. ; Buzdar, A. U. ; Nagel, G. A. ; Henderson, I. C. / Aminoglutethimide-induced hematologic toxicity : Worldwide experience. In: Cancer Treatment Reports. 1985 ; Vol. 69, No. 9. pp. 1003-1004.
@article{3d206117ec864e8e87a57982480e1484,
title = "Aminoglutethimide-induced hematologic toxicity: Worldwide experience",
abstract = "Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9{\%} incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.",
author = "Messeih, {A. A.} and Allan Lipton and Santen, {R. J.} and Harold Harvey and Boucher, {A. E.} and R. Murray and J. Ragaz and Buzdar, {A. U.} and Nagel, {G. A.} and Henderson, {I. C.}",
year = "1985",
month = "12",
day = "11",
language = "English (US)",
volume = "69",
pages = "1003--1004",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "9",

}

Messeih, AA, Lipton, A, Santen, RJ, Harvey, H, Boucher, AE, Murray, R, Ragaz, J, Buzdar, AU, Nagel, GA & Henderson, IC 1985, 'Aminoglutethimide-induced hematologic toxicity: Worldwide experience', Cancer Treatment Reports, vol. 69, no. 9, pp. 1003-1004.

Aminoglutethimide-induced hematologic toxicity : Worldwide experience. / Messeih, A. A.; Lipton, Allan; Santen, R. J.; Harvey, Harold; Boucher, A. E.; Murray, R.; Ragaz, J.; Buzdar, A. U.; Nagel, G. A.; Henderson, I. C.

In: Cancer Treatment Reports, Vol. 69, No. 9, 11.12.1985, p. 1003-1004.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aminoglutethimide-induced hematologic toxicity

T2 - Worldwide experience

AU - Messeih, A. A.

AU - Lipton, Allan

AU - Santen, R. J.

AU - Harvey, Harold

AU - Boucher, A. E.

AU - Murray, R.

AU - Ragaz, J.

AU - Buzdar, A. U.

AU - Nagel, G. A.

AU - Henderson, I. C.

PY - 1985/12/11

Y1 - 1985/12/11

N2 - Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

AB - Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

UR - http://www.scopus.com/inward/record.url?scp=0022005835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022005835&partnerID=8YFLogxK

M3 - Article

C2 - 4028032

AN - SCOPUS:0022005835

VL - 69

SP - 1003

EP - 1004

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 9

ER -

Messeih AA, Lipton A, Santen RJ, Harvey H, Boucher AE, Murray R et al. Aminoglutethimide-induced hematologic toxicity: Worldwide experience. Cancer Treatment Reports. 1985 Dec 11;69(9):1003-1004.