Aminoglutethimide vs. Surgical Adrenalectomy in Breast Cancer

Alfred I. Neugut, Paul Meier, Anne Naysmith, U. Chetty, R. J.C. Steele, R. C. Mason, A. P.M. Forrest, Richard J. Santen, Thomas J. Worgul, Eugeniusz Samojlik, Albert Interrante, Alice E. Boucher, Allan Lipton, Harold Harvey, Deborah S. White, Emma Smart, Charles Cox, Samuel A. Wells

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: The paper in the September 3 issue by Santen et al.,1 comparing surgical adrenalectomy with“medical adrenalectomy”using aminoglutethimide in the treatment of advanced breast cancer makes a strong argument for the increased use of hormonal therapy, as discussed in the accompanying editorial.2 However, the comparison of the two therapies has serious methodologic errors. The authors state that they used a modification of the method of Zelen3 in designing a randomized trial wherein randomization preceded the obtaining of informed consent. Yet a key ingredient of Zelen's design is that patients who refuse the experimental treatment must.

Original languageEnglish (US)
Pages (from-to)44-46
Number of pages3
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jan 7 1982

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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