Amiodarone: Pharmacology and Antiarrhythmic and Adverse Effects

Gerald Naccarelli; Robert L. Rinkenberger; Anne H. Dougherty; Ruth A. Giebel

doi:10.1002/j.1875-9114.1985.tb03434.x

Amiodarone: Pharmacology and Antiarrhythmic and Adverse Effects

Gerald Naccarelli, Robert L. Rinkenberger, Anne H. Dougherty, Ruth A. Giebel

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half‐life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2‐compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life‐threatening arrhythmias. 1985 Pharmacotherapy Publications Inc.

Original language	English (US)
Pages (from-to)	298-311
Number of pages	14
Journal	Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/j.1875-9114.1985.tb03434.x
State	Published - Jan 1 1985

All Science Journal Classification (ASJC) codes

Pharmacology (medical)

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10.1002/j.1875-9114.1985.tb03434.x

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AB - Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half‐life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2‐compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life‐threatening arrhythmias. 1985 Pharmacotherapy Publications Inc.

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Amiodarone: Pharmacology and Antiarrhythmic and Adverse Effects

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All Science Journal Classification (ASJC) codes

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