Amnesia induced by 2-Deoxygalactose in the day-old chick: lateralization of effects in two different one-trial learning tasks

Alistair Barber, Steven P.R. Rose

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

2-Deoxy-d-galactose, an inhibitor of brain glycoprotein fucosylation, was injected intracranially (10 μmole dose in 10 μl) into either the left or the right forebrain hemisphere of day-old chicks (Gallus domesticus). Bilateral injection of this dose of 2-deoxy-d-galactose is known to induce amnesia for several learning tasks including one-trial passive avoidance and sickness-induced learning. When a tritiated form of the drug was injected into one forebrain hemisphere only, a significantly large proportion of the dose remained in that hemisphere. Chicks were trained in two different one-trial learning tasks. The first was a passive avoidance task in which the chicks were allowed to peck at a green training stimulus (a small light-emitting diode, LED) coated in the bitter liquid, methylanthranilate, giving rise to a strong disgust response and consequent avoidance of the green stimulus. In the second paradigm the chicks were allowed to peck at a similarly colored dry stimulus but, 30 min later, were injected intraperitoneally with lithium chloride (0.1 ml of 1 M solution), causing a sickness-induced aversion for the green LED. 2-Deoxy-d-galactose caused amnesia for the passive avoidance task when injected before training into the right hemisphere but not the left. However, unilateral injection of the drug before training on the sickness-induced learning task did not cause amnesia. The results indicate that fucosylation of brain glycoproteins is required in the right hemisphere for learning the passive avoidance task but that memory for sickness-induced learning can be retained by either hemisphere.

Original languageEnglish (US)
Pages (from-to)77-88
Number of pages12
JournalBehavioral and Neural Biology
Volume56
Issue number1
DOIs
StatePublished - Jan 1 1991

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Amnesia
Fucose
Learning
Galactose
Prosencephalon
Glycoproteins
Avoidance Learning
Lithium Chloride
Methyl Green
Injections
Brain
Pharmaceutical Preparations
Chickens
Light

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

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title = "Amnesia induced by 2-Deoxygalactose in the day-old chick: lateralization of effects in two different one-trial learning tasks",
abstract = "2-Deoxy-d-galactose, an inhibitor of brain glycoprotein fucosylation, was injected intracranially (10 μmole dose in 10 μl) into either the left or the right forebrain hemisphere of day-old chicks (Gallus domesticus). Bilateral injection of this dose of 2-deoxy-d-galactose is known to induce amnesia for several learning tasks including one-trial passive avoidance and sickness-induced learning. When a tritiated form of the drug was injected into one forebrain hemisphere only, a significantly large proportion of the dose remained in that hemisphere. Chicks were trained in two different one-trial learning tasks. The first was a passive avoidance task in which the chicks were allowed to peck at a green training stimulus (a small light-emitting diode, LED) coated in the bitter liquid, methylanthranilate, giving rise to a strong disgust response and consequent avoidance of the green stimulus. In the second paradigm the chicks were allowed to peck at a similarly colored dry stimulus but, 30 min later, were injected intraperitoneally with lithium chloride (0.1 ml of 1 M solution), causing a sickness-induced aversion for the green LED. 2-Deoxy-d-galactose caused amnesia for the passive avoidance task when injected before training into the right hemisphere but not the left. However, unilateral injection of the drug before training on the sickness-induced learning task did not cause amnesia. The results indicate that fucosylation of brain glycoproteins is required in the right hemisphere for learning the passive avoidance task but that memory for sickness-induced learning can be retained by either hemisphere.",
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Amnesia induced by 2-Deoxygalactose in the day-old chick : lateralization of effects in two different one-trial learning tasks. / Barber, Alistair; Rose, Steven P.R.

In: Behavioral and Neural Biology, Vol. 56, No. 1, 01.01.1991, p. 77-88.

Research output: Contribution to journalArticle

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