Abstract
2-Deoxy-d-galactose, an inhibitor of brain glycoprotein fucosylation, was injected intracranially (10 μmole dose in 10 μl) into either the left or the right forebrain hemisphere of day-old chicks (Gallus domesticus). Bilateral injection of this dose of 2-deoxy-d-galactose is known to induce amnesia for several learning tasks including one-trial passive avoidance and sickness-induced learning. When a tritiated form of the drug was injected into one forebrain hemisphere only, a significantly large proportion of the dose remained in that hemisphere. Chicks were trained in two different one-trial learning tasks. The first was a passive avoidance task in which the chicks were allowed to peck at a green training stimulus (a small light-emitting diode, LED) coated in the bitter liquid, methylanthranilate, giving rise to a strong disgust response and consequent avoidance of the green stimulus. In the second paradigm the chicks were allowed to peck at a similarly colored dry stimulus but, 30 min later, were injected intraperitoneally with lithium chloride (0.1 ml of 1 M solution), causing a sickness-induced aversion for the green LED. 2-Deoxy-d-galactose caused amnesia for the passive avoidance task when injected before training into the right hemisphere but not the left. However, unilateral injection of the drug before training on the sickness-induced learning task did not cause amnesia. The results indicate that fucosylation of brain glycoproteins is required in the right hemisphere for learning the passive avoidance task but that memory for sickness-induced learning can be retained by either hemisphere.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-88 |
| Number of pages | 12 |
| Journal | Behavioral and Neural Biology |
| Volume | 56 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1991 |
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All Science Journal Classification (ASJC) codes
- Physiology
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Amnesia induced by 2-Deoxygalactose in the day-old chick : lateralization of effects in two different one-trial learning tasks. / Barber, Alistair; Rose, Steven P.R.
In: Behavioral and Neural Biology, Vol. 56, No. 1, 01.01.1991, p. 77-88.Research output: Contribution to journal › Article
TY - JOUR
T1 - Amnesia induced by 2-Deoxygalactose in the day-old chick
T2 - lateralization of effects in two different one-trial learning tasks
AU - Barber, Alistair
AU - Rose, Steven P.R.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - 2-Deoxy-d-galactose, an inhibitor of brain glycoprotein fucosylation, was injected intracranially (10 μmole dose in 10 μl) into either the left or the right forebrain hemisphere of day-old chicks (Gallus domesticus). Bilateral injection of this dose of 2-deoxy-d-galactose is known to induce amnesia for several learning tasks including one-trial passive avoidance and sickness-induced learning. When a tritiated form of the drug was injected into one forebrain hemisphere only, a significantly large proportion of the dose remained in that hemisphere. Chicks were trained in two different one-trial learning tasks. The first was a passive avoidance task in which the chicks were allowed to peck at a green training stimulus (a small light-emitting diode, LED) coated in the bitter liquid, methylanthranilate, giving rise to a strong disgust response and consequent avoidance of the green stimulus. In the second paradigm the chicks were allowed to peck at a similarly colored dry stimulus but, 30 min later, were injected intraperitoneally with lithium chloride (0.1 ml of 1 M solution), causing a sickness-induced aversion for the green LED. 2-Deoxy-d-galactose caused amnesia for the passive avoidance task when injected before training into the right hemisphere but not the left. However, unilateral injection of the drug before training on the sickness-induced learning task did not cause amnesia. The results indicate that fucosylation of brain glycoproteins is required in the right hemisphere for learning the passive avoidance task but that memory for sickness-induced learning can be retained by either hemisphere.
AB - 2-Deoxy-d-galactose, an inhibitor of brain glycoprotein fucosylation, was injected intracranially (10 μmole dose in 10 μl) into either the left or the right forebrain hemisphere of day-old chicks (Gallus domesticus). Bilateral injection of this dose of 2-deoxy-d-galactose is known to induce amnesia for several learning tasks including one-trial passive avoidance and sickness-induced learning. When a tritiated form of the drug was injected into one forebrain hemisphere only, a significantly large proportion of the dose remained in that hemisphere. Chicks were trained in two different one-trial learning tasks. The first was a passive avoidance task in which the chicks were allowed to peck at a green training stimulus (a small light-emitting diode, LED) coated in the bitter liquid, methylanthranilate, giving rise to a strong disgust response and consequent avoidance of the green stimulus. In the second paradigm the chicks were allowed to peck at a similarly colored dry stimulus but, 30 min later, were injected intraperitoneally with lithium chloride (0.1 ml of 1 M solution), causing a sickness-induced aversion for the green LED. 2-Deoxy-d-galactose caused amnesia for the passive avoidance task when injected before training into the right hemisphere but not the left. However, unilateral injection of the drug before training on the sickness-induced learning task did not cause amnesia. The results indicate that fucosylation of brain glycoproteins is required in the right hemisphere for learning the passive avoidance task but that memory for sickness-induced learning can be retained by either hemisphere.
UR - http://www.scopus.com/inward/record.url?scp=0025895902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025895902&partnerID=8YFLogxK
U2 - 10.1016/0163-1047(91)90303-8
DO - 10.1016/0163-1047(91)90303-8
M3 - Article
C2 - 1867628
AN - SCOPUS:0025895902
VL - 56
SP - 77
EP - 88
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
IS - 1
ER -