Amperometric Measurements and Dynamic Models Reveal a Mechanism for How Zinc Alters Neurotransmitter Release

Lin Ren, Alexander Oleinick, Irina Svir, Christian Amatore, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Zinc, a suspected potentiator of learning and memory, is shown to affect exocytotic release and storage in neurotransmitter-containing vesicles. Structural and size analysis of the vesicular dense core and halo using transmission electron microscopy was combined with single-cell amperometry to study the vesicle size changes induced after zinc treatment and to compare these changes to theoretical predictions based on the concept of partial release as opposed to full quantal release. This powerful combined analytical approach establishes the existence of an unsuspected strong link between vesicle structure and exocytotic dynamics, which can be used to explain the mechanism of regulation of synaptic plasticity by Zn2+ through modulation of neurotransmitter release.

Original languageEnglish (US)
Pages (from-to)3083-3087
Number of pages5
JournalAngewandte Chemie - International Edition
Volume59
Issue number8
DOIs
StatePublished - Feb 17 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Fingerprint

Dive into the research topics of 'Amperometric Measurements and Dynamic Models Reveal a Mechanism for How Zinc Alters Neurotransmitter Release'. Together they form a unique fingerprint.

Cite this