Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking

Harry R. Allcock, M. Gebura, S. Kwon, T. X. Neenan

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Abstract

The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x (NHCH3)y]n and [NP(OC6H5)x (NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]n by trifluoroethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to γ radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)z]n, [NP(OC6,H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking process appeared to involve free radical reactions at the methyl groups of the methylamino substituants. The possible utility of these materials in biomedical research is discussed.

Original languageEnglish (US)
Pages (from-to)500-508
Number of pages9
JournalBiomaterials
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1988

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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