Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer

Meixian Xiang, Hanwen Su, Guangwen Shu, Dingrong Wan, Feng He, Morgann Loaec, Yali Ding, Jun Li, Sinisa Dovat, Gaungzhong Yang, Chunhua Song

Research output: Contribution to journalArticle

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Abstract

Chemotherapy is the main treatment for patients with breast cancer metastases, but natural alternatives have been receiving attention for their potential as novel antitumor reagents. Amplexicaule A (APA) is a flavonoid glucoside isolated from rhizomes of Polygonum amplexicaule D. Don var. sinense Forb (PADF). We found that APA has anti-tumor effects in a breast cancer xenograft mouse model and induces apoptosis in breast cancer cell lines. APA increased levels of cleaved caspase-3,-8,-9 and PARP, which resulted from suppression of MCL-1 and BCL-2 expression in the cells. APA also inactivated the Akt/mTOR pathway in breast cancer cells. Thus, APA exerts a strong anti-tumor effect on breast cancer cells, most likely through induction of apoptosis. Our study is the first to identify this novel anti-tumor compound and provides a new strategy for isolation and separation of single compounds from herbs.

Original languageEnglish (US)
Pages (from-to)18521-18530
Number of pages10
JournalOncotarget
Volume7
Issue number14
DOIs
StatePublished - Jan 1 2016

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All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Xiang, M., Su, H., Shu, G., Wan, D., He, F., Loaec, M., Ding, Y., Li, J., Dovat, S., Yang, G., & Song, C. (2016). Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer. Oncotarget, 7(14), 18521-18530. https://doi.org/10.18632/oncotarget.7848