Amplifiers

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Synaptic transmission often occurs at the current level of pico-amperes. Because of the microscopic currents generated, they must be collected and amplified before they can be examined and analyzed. This job is done by the micro-amplifier. The amplifier directly connects to the electrode acquiring electrical signals from the targeted cell or brain regions. Thanks to advances in semiconducting technology, most amplifiers are light-weight, but extremely efficient in achieving stable, low-noise recordings. Combined with userfriendly software, operating the amplifier requires little effort. We have witnessed several occasions that without any prior experience, an undergraduate student successfully recorded synaptic transmission and collected useful data in a well-tuned setup. Nonetheless, these user-friendly features of the hardware and software are also risky because investigators need to know far less about the underlying mechanisms of their operation before they can start collecting data. This can lead to erroneous results. Here we summarize several basic properties of the preamplifier, with the hope that by knowing these properties, some obvious mistakes can be avoided

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages33-53
Number of pages21
DOIs
StatePublished - Oct 1 2016

Publication series

NameNeuromethods
Volume112
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Fingerprint

Synaptic Transmission
Software
Noise
Electrodes
Light amplifiers
Research Personnel
Students
Technology
Weights and Measures
Brain
Hardware

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

Cite this

Graziane, N., & Dong, Y. (2016). Amplifiers. In Neuromethods (pp. 33-53). (Neuromethods; Vol. 112). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3274-0_3
Graziane, Nicholas ; Dong, Yan. / Amplifiers. Neuromethods. Humana Press Inc., 2016. pp. 33-53 (Neuromethods).
@inbook{e46b928878ef4d4a9c04cc3751373b0e,
title = "Amplifiers",
abstract = "Synaptic transmission often occurs at the current level of pico-amperes. Because of the microscopic currents generated, they must be collected and amplified before they can be examined and analyzed. This job is done by the micro-amplifier. The amplifier directly connects to the electrode acquiring electrical signals from the targeted cell or brain regions. Thanks to advances in semiconducting technology, most amplifiers are light-weight, but extremely efficient in achieving stable, low-noise recordings. Combined with userfriendly software, operating the amplifier requires little effort. We have witnessed several occasions that without any prior experience, an undergraduate student successfully recorded synaptic transmission and collected useful data in a well-tuned setup. Nonetheless, these user-friendly features of the hardware and software are also risky because investigators need to know far less about the underlying mechanisms of their operation before they can start collecting data. This can lead to erroneous results. Here we summarize several basic properties of the preamplifier, with the hope that by knowing these properties, some obvious mistakes can be avoided",
author = "Nicholas Graziane and Yan Dong",
year = "2016",
month = "10",
day = "1",
doi = "10.1007/978-1-4939-3274-0_3",
language = "English (US)",
series = "Neuromethods",
publisher = "Humana Press Inc.",
pages = "33--53",
booktitle = "Neuromethods",

}

Graziane, N & Dong, Y 2016, Amplifiers. in Neuromethods. Neuromethods, vol. 112, Humana Press Inc., pp. 33-53. https://doi.org/10.1007/978-1-4939-3274-0_3

Amplifiers. / Graziane, Nicholas; Dong, Yan.

Neuromethods. Humana Press Inc., 2016. p. 33-53 (Neuromethods; Vol. 112).

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Amplifiers

AU - Graziane, Nicholas

AU - Dong, Yan

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Synaptic transmission often occurs at the current level of pico-amperes. Because of the microscopic currents generated, they must be collected and amplified before they can be examined and analyzed. This job is done by the micro-amplifier. The amplifier directly connects to the electrode acquiring electrical signals from the targeted cell or brain regions. Thanks to advances in semiconducting technology, most amplifiers are light-weight, but extremely efficient in achieving stable, low-noise recordings. Combined with userfriendly software, operating the amplifier requires little effort. We have witnessed several occasions that without any prior experience, an undergraduate student successfully recorded synaptic transmission and collected useful data in a well-tuned setup. Nonetheless, these user-friendly features of the hardware and software are also risky because investigators need to know far less about the underlying mechanisms of their operation before they can start collecting data. This can lead to erroneous results. Here we summarize several basic properties of the preamplifier, with the hope that by knowing these properties, some obvious mistakes can be avoided

AB - Synaptic transmission often occurs at the current level of pico-amperes. Because of the microscopic currents generated, they must be collected and amplified before they can be examined and analyzed. This job is done by the micro-amplifier. The amplifier directly connects to the electrode acquiring electrical signals from the targeted cell or brain regions. Thanks to advances in semiconducting technology, most amplifiers are light-weight, but extremely efficient in achieving stable, low-noise recordings. Combined with userfriendly software, operating the amplifier requires little effort. We have witnessed several occasions that without any prior experience, an undergraduate student successfully recorded synaptic transmission and collected useful data in a well-tuned setup. Nonetheless, these user-friendly features of the hardware and software are also risky because investigators need to know far less about the underlying mechanisms of their operation before they can start collecting data. This can lead to erroneous results. Here we summarize several basic properties of the preamplifier, with the hope that by knowing these properties, some obvious mistakes can be avoided

UR - http://www.scopus.com/inward/record.url?scp=84949978440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949978440&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-3274-0_3

DO - 10.1007/978-1-4939-3274-0_3

M3 - Chapter

T3 - Neuromethods

SP - 33

EP - 53

BT - Neuromethods

PB - Humana Press Inc.

ER -

Graziane N, Dong Y. Amplifiers. In Neuromethods. Humana Press Inc. 2016. p. 33-53. (Neuromethods). https://doi.org/10.1007/978-1-4939-3274-0_3