An abbreviated synthesis of 7,12-dimethylbenz[a]anthracene and benzo[c]chrysene metabolites using the Suzuki reaction

Arun Sharma, Shantu Amin, Subodh Kumar

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Efficient syntheses of important metabolites of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[c]chrysene (B[c]C), via Suzuki coupling reaction are described. This approach provides an excellent method for the preparation of 3-methoxy-DMBA 5, 10-methoxy-B[c]C 14 and 2-methoxy B[c]C 20, and hence for the corresponding dihydrodiols 6, 15, and 21. Following a similar Suzuki reaction, DMBA-6(5 H)-one 8 was also synthesized in high yield.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalPolycyclic Aromatic Compounds
Volume22
Issue number3-4
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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