Efficient syntheses of important metabolites of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[c]chrysene (B[c]C), via Suzuki coupling reaction are described. This approach provides an excellent method for the preparation of 3-methoxy-DMBA 5, 10-methoxy-B[c]C 14 and 2-methoxy B[c]C 20, and hence for the corresponding dihydrodiols 6, 15, and 21. Following a similar Suzuki reaction, DMBA-6(5 H)-one 8 was also synthesized in high yield.
All Science Journal Classification (ASJC) codes
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry