An active transport system in the blood-brain barrier may reduce levodopa availability

Richard A. Hawkins, Ashwini Mokashi, Ian Simpson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Levodopa, the primary drug used to treat patients with Parkinson's disease, is transported into the brain by the facilitative amino acid transporter (L1). We present here an unanticipated discovery: levodopa may be pumped out of the brain by a Na+-dependent transport system that couples the naturally occurring Na+ gradient existing between the brain's extracellular fluid and the cytoplasm of capillary endothelial cells. The activity of this system reduces the net availability of levodopa.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalExperimental Neurology
Volume195
Issue number1
DOIs
StatePublished - Sep 1 2005

Fingerprint

Active Biological Transport
Levodopa
Blood-Brain Barrier
Brain
Amino Acid Transport Systems
Extracellular Fluid
Parkinson Disease
Cytoplasm
Endothelial Cells
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

Cite this

Hawkins, Richard A. ; Mokashi, Ashwini ; Simpson, Ian. / An active transport system in the blood-brain barrier may reduce levodopa availability. In: Experimental Neurology. 2005 ; Vol. 195, No. 1. pp. 267-271.
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An active transport system in the blood-brain barrier may reduce levodopa availability. / Hawkins, Richard A.; Mokashi, Ashwini; Simpson, Ian.

In: Experimental Neurology, Vol. 195, No. 1, 01.09.2005, p. 267-271.

Research output: Contribution to journalArticle

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