An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication

B. M. Quintela, J. M. Conway, J. M. Hyman, R. F. Reis, R. W. dos Santos, M. Lobosco, A. S. Perelson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.

Original languageEnglish (US)
Title of host publication7th Latin American Congress on Biomedical Engineering, CLAIB 2016
EditorsJohn Bustamante, Daniel A. Sierra, Isnardo Torres
PublisherSpringer Verlag
Pages508-511
Number of pages4
ISBN (Print)9789811040856
DOIs
StatePublished - Jan 1 2017
Event7th Latin American Congress on Biomedical Engineering, CLAIB 2016 - Bucaramanga, Santander, Colombia
Duration: Oct 26 2016Oct 28 2016

Publication series

NameIFMBE Proceedings
Volume60
ISSN (Print)1680-0737

Other

Other7th Latin American Congress on Biomedical Engineering, CLAIB 2016
CountryColombia
CityBucaramanga, Santander
Period10/26/1610/28/16

Fingerprint

Viruses
Life cycle
Mathematical models
RNA
Antiviral Agents
Plasmas
Experiments

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Quintela, B. M., Conway, J. M., Hyman, J. M., Reis, R. F., dos Santos, R. W., Lobosco, M., & Perelson, A. S. (2017). An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. In J. Bustamante, D. A. Sierra, & I. Torres (Eds.), 7th Latin American Congress on Biomedical Engineering, CLAIB 2016 (pp. 508-511). (IFMBE Proceedings; Vol. 60). Springer Verlag. https://doi.org/10.1007/978-981-10-4086-3_128
Quintela, B. M. ; Conway, J. M. ; Hyman, J. M. ; Reis, R. F. ; dos Santos, R. W. ; Lobosco, M. ; Perelson, A. S. / An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy : Including translation and replication. 7th Latin American Congress on Biomedical Engineering, CLAIB 2016. editor / John Bustamante ; Daniel A. Sierra ; Isnardo Torres. Springer Verlag, 2017. pp. 508-511 (IFMBE Proceedings).
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abstract = "The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.",
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Quintela, BM, Conway, JM, Hyman, JM, Reis, RF, dos Santos, RW, Lobosco, M & Perelson, AS 2017, An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. in J Bustamante, DA Sierra & I Torres (eds), 7th Latin American Congress on Biomedical Engineering, CLAIB 2016. IFMBE Proceedings, vol. 60, Springer Verlag, pp. 508-511, 7th Latin American Congress on Biomedical Engineering, CLAIB 2016, Bucaramanga, Santander, Colombia, 10/26/16. https://doi.org/10.1007/978-981-10-4086-3_128

An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy : Including translation and replication. / Quintela, B. M.; Conway, J. M.; Hyman, J. M.; Reis, R. F.; dos Santos, R. W.; Lobosco, M.; Perelson, A. S.

7th Latin American Congress on Biomedical Engineering, CLAIB 2016. ed. / John Bustamante; Daniel A. Sierra; Isnardo Torres. Springer Verlag, 2017. p. 508-511 (IFMBE Proceedings; Vol. 60).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.

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Quintela BM, Conway JM, Hyman JM, Reis RF, dos Santos RW, Lobosco M et al. An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. In Bustamante J, Sierra DA, Torres I, editors, 7th Latin American Congress on Biomedical Engineering, CLAIB 2016. Springer Verlag. 2017. p. 508-511. (IFMBE Proceedings). https://doi.org/10.1007/978-981-10-4086-3_128