Abstract
1. 1. Attempts to produce complete animal models of human disorders of the CNS have had limited success. 2. 2. By having alternative approaches to the production of "true" models of CNS disease, animal research has been able to make significant contributions to our understanding of central disease mechanisms. 3. 3. One alternative includes an examination of the mechanism(s) of action of drugs which alter symptoms of disorders of the CNS. 4. 4. Another approach has been the study of underlying neurobiological mechanisms of individual functions which are abnormal in central diseases. 5. 5. This overview provides examples of research which have extended our knowledge about CNS disorders and outlines some of the difficulties in interpretation encountered when these approaches are used.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-325 |
| Number of pages | 13 |
| Journal | Progress in Neuro-Psychopharmacology |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1978 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Psychiatry and Mental health
- Pharmacology (medical)
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An alternative to animal models of central nervous system disorders : Study of drug mechanisms and disease symptoms in animals. / Breese, George R.; Mueller, Robert A.; Mailman, Richard; Frye, Gerald D.; Vogel, Richard A.
In: Progress in Neuro-Psychopharmacology, Vol. 2, No. 3, 01.01.1978, p. 313-325.Research output: Contribution to journal › Review article
TY - JOUR
T1 - An alternative to animal models of central nervous system disorders
T2 - Study of drug mechanisms and disease symptoms in animals
AU - Breese, George R.
AU - Mueller, Robert A.
AU - Mailman, Richard
AU - Frye, Gerald D.
AU - Vogel, Richard A.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - 1. 1. Attempts to produce complete animal models of human disorders of the CNS have had limited success. 2. 2. By having alternative approaches to the production of "true" models of CNS disease, animal research has been able to make significant contributions to our understanding of central disease mechanisms. 3. 3. One alternative includes an examination of the mechanism(s) of action of drugs which alter symptoms of disorders of the CNS. 4. 4. Another approach has been the study of underlying neurobiological mechanisms of individual functions which are abnormal in central diseases. 5. 5. This overview provides examples of research which have extended our knowledge about CNS disorders and outlines some of the difficulties in interpretation encountered when these approaches are used.
AB - 1. 1. Attempts to produce complete animal models of human disorders of the CNS have had limited success. 2. 2. By having alternative approaches to the production of "true" models of CNS disease, animal research has been able to make significant contributions to our understanding of central disease mechanisms. 3. 3. One alternative includes an examination of the mechanism(s) of action of drugs which alter symptoms of disorders of the CNS. 4. 4. Another approach has been the study of underlying neurobiological mechanisms of individual functions which are abnormal in central diseases. 5. 5. This overview provides examples of research which have extended our knowledge about CNS disorders and outlines some of the difficulties in interpretation encountered when these approaches are used.
UR - http://www.scopus.com/inward/record.url?scp=0018127392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018127392&partnerID=8YFLogxK
U2 - 10.1016/0364-7722(78)90089-9
DO - 10.1016/0364-7722(78)90089-9
M3 - Review article
VL - 2
SP - 313
EP - 325
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 3
ER -