An Analysis of Select Emerging Executive Skills in Perinatally HIV-1-Infected Children

Antolin Llorente, Pim Brouwers, Robert Leighty, Kathleen Malee, Renee Smith, Lynnette Harris, Leslie K. Serchuck, Ileana Blasini, Cynthia Chase

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study examined the effect of perinatal HIV-1 infection on emerging executive skills in children (n = 161) ages 8 to 12 years. HIV-positive (n = 76) and HIV-negative (n = 85) children were eligible to participate. The HIV-positive children included those who had experienced a CDC Class C event (greater severity, n = 22) and those who were HIV-positive but who had not experienced a CDC Class C event (less severity, n = 54). Measures of emerging executive functions completed by the children included subtests from the Developmental Neuropsychological Assessment (NEPSY), the Trail-Making Test-Part B, and a subtest from the Woodcock-Johnson Battery-Revised. Ratings of executive functions were obtained from caretakers using the Behavior Rating Inventory of Executive Functions. Generalized estimating equations methods, discriminate analyses, and global deficit score analyses were performed to determine whether differences emerged between the three clinical groups while using strict controls. The present results revealed significant group differences in unadjusted mean scores measuring executive functioning. However, such differences did not remain statistically significant when moderating variables were taken into consideration in the models. The apparent deficit in executive functioning for the HIV-positive children was found to be largely due to differential psychosocial and environmental factors rather than HIV disease and its severity, and in this cohort, the effects of HIV-1 infection on emerging executive functions appeared to be negligible when controlling for treatment and moderating psychosocial variables.

Original languageEnglish (US)
Pages (from-to)10-25
Number of pages16
JournalApplied Neuropsychology: Child
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

HIV-1
Executive Function
HIV
Centers for Disease Control and Prevention (U.S.)
HIV Infections
Trail Making Test
Cohort Effect
Psychology
Equipment and Supplies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology

Cite this

Llorente, Antolin ; Brouwers, Pim ; Leighty, Robert ; Malee, Kathleen ; Smith, Renee ; Harris, Lynnette ; Serchuck, Leslie K. ; Blasini, Ileana ; Chase, Cynthia. / An Analysis of Select Emerging Executive Skills in Perinatally HIV-1-Infected Children. In: Applied Neuropsychology: Child. 2014 ; Vol. 3, No. 1. pp. 10-25.
@article{22f4b58a2e0649d288ed97832a13ba64,
title = "An Analysis of Select Emerging Executive Skills in Perinatally HIV-1-Infected Children",
abstract = "This study examined the effect of perinatal HIV-1 infection on emerging executive skills in children (n = 161) ages 8 to 12 years. HIV-positive (n = 76) and HIV-negative (n = 85) children were eligible to participate. The HIV-positive children included those who had experienced a CDC Class C event (greater severity, n = 22) and those who were HIV-positive but who had not experienced a CDC Class C event (less severity, n = 54). Measures of emerging executive functions completed by the children included subtests from the Developmental Neuropsychological Assessment (NEPSY), the Trail-Making Test-Part B, and a subtest from the Woodcock-Johnson Battery-Revised. Ratings of executive functions were obtained from caretakers using the Behavior Rating Inventory of Executive Functions. Generalized estimating equations methods, discriminate analyses, and global deficit score analyses were performed to determine whether differences emerged between the three clinical groups while using strict controls. The present results revealed significant group differences in unadjusted mean scores measuring executive functioning. However, such differences did not remain statistically significant when moderating variables were taken into consideration in the models. The apparent deficit in executive functioning for the HIV-positive children was found to be largely due to differential psychosocial and environmental factors rather than HIV disease and its severity, and in this cohort, the effects of HIV-1 infection on emerging executive functions appeared to be negligible when controlling for treatment and moderating psychosocial variables.",
author = "Antolin Llorente and Pim Brouwers and Robert Leighty and Kathleen Malee and Renee Smith and Lynnette Harris and Serchuck, {Leslie K.} and Ileana Blasini and Cynthia Chase",
year = "2014",
month = "1",
day = "1",
doi = "10.1080/21622965.2012.686853",
language = "English (US)",
volume = "3",
pages = "10--25",
journal = "Applied Neuropsychology: Child",
issn = "2162-2965",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

Llorente, A, Brouwers, P, Leighty, R, Malee, K, Smith, R, Harris, L, Serchuck, LK, Blasini, I & Chase, C 2014, 'An Analysis of Select Emerging Executive Skills in Perinatally HIV-1-Infected Children', Applied Neuropsychology: Child, vol. 3, no. 1, pp. 10-25. https://doi.org/10.1080/21622965.2012.686853

An Analysis of Select Emerging Executive Skills in Perinatally HIV-1-Infected Children. / Llorente, Antolin; Brouwers, Pim; Leighty, Robert; Malee, Kathleen; Smith, Renee; Harris, Lynnette; Serchuck, Leslie K.; Blasini, Ileana; Chase, Cynthia.

In: Applied Neuropsychology: Child, Vol. 3, No. 1, 01.01.2014, p. 10-25.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An Analysis of Select Emerging Executive Skills in Perinatally HIV-1-Infected Children

AU - Llorente, Antolin

AU - Brouwers, Pim

AU - Leighty, Robert

AU - Malee, Kathleen

AU - Smith, Renee

AU - Harris, Lynnette

AU - Serchuck, Leslie K.

AU - Blasini, Ileana

AU - Chase, Cynthia

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This study examined the effect of perinatal HIV-1 infection on emerging executive skills in children (n = 161) ages 8 to 12 years. HIV-positive (n = 76) and HIV-negative (n = 85) children were eligible to participate. The HIV-positive children included those who had experienced a CDC Class C event (greater severity, n = 22) and those who were HIV-positive but who had not experienced a CDC Class C event (less severity, n = 54). Measures of emerging executive functions completed by the children included subtests from the Developmental Neuropsychological Assessment (NEPSY), the Trail-Making Test-Part B, and a subtest from the Woodcock-Johnson Battery-Revised. Ratings of executive functions were obtained from caretakers using the Behavior Rating Inventory of Executive Functions. Generalized estimating equations methods, discriminate analyses, and global deficit score analyses were performed to determine whether differences emerged between the three clinical groups while using strict controls. The present results revealed significant group differences in unadjusted mean scores measuring executive functioning. However, such differences did not remain statistically significant when moderating variables were taken into consideration in the models. The apparent deficit in executive functioning for the HIV-positive children was found to be largely due to differential psychosocial and environmental factors rather than HIV disease and its severity, and in this cohort, the effects of HIV-1 infection on emerging executive functions appeared to be negligible when controlling for treatment and moderating psychosocial variables.

AB - This study examined the effect of perinatal HIV-1 infection on emerging executive skills in children (n = 161) ages 8 to 12 years. HIV-positive (n = 76) and HIV-negative (n = 85) children were eligible to participate. The HIV-positive children included those who had experienced a CDC Class C event (greater severity, n = 22) and those who were HIV-positive but who had not experienced a CDC Class C event (less severity, n = 54). Measures of emerging executive functions completed by the children included subtests from the Developmental Neuropsychological Assessment (NEPSY), the Trail-Making Test-Part B, and a subtest from the Woodcock-Johnson Battery-Revised. Ratings of executive functions were obtained from caretakers using the Behavior Rating Inventory of Executive Functions. Generalized estimating equations methods, discriminate analyses, and global deficit score analyses were performed to determine whether differences emerged between the three clinical groups while using strict controls. The present results revealed significant group differences in unadjusted mean scores measuring executive functioning. However, such differences did not remain statistically significant when moderating variables were taken into consideration in the models. The apparent deficit in executive functioning for the HIV-positive children was found to be largely due to differential psychosocial and environmental factors rather than HIV disease and its severity, and in this cohort, the effects of HIV-1 infection on emerging executive functions appeared to be negligible when controlling for treatment and moderating psychosocial variables.

UR - http://www.scopus.com/inward/record.url?scp=84887925109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887925109&partnerID=8YFLogxK

U2 - 10.1080/21622965.2012.686853

DO - 10.1080/21622965.2012.686853

M3 - Article

C2 - 24236937

AN - SCOPUS:84887925109

VL - 3

SP - 10

EP - 25

JO - Applied Neuropsychology: Child

JF - Applied Neuropsychology: Child

SN - 2162-2965

IS - 1

ER -