An analysis of the inter-relationships among multiple bronchoalveolar lavage and serum determinations, physiologic tests, and clinical disease activity in patients with sarcoidosis.

J. A. Rankin, S. S. Huang, H. D. Sostman, J. B. Gee, Herbert Reynolds

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Analysis of epithelial lining fluid from the lungs of patients with sarcoidosis frequently suggests the presence of an alveolitis. Several markers of this inflammatory response were quantitated in bronchoalveolar lavage fluid and serum from 45 non-smoking patients with sarcoidosis. All markers were elevated significantly compared to those from 19 normal controls. The degree of statistical correlation among all data was assessed. Pulmonary function tests, 67Gallium lung scans, and a clinical index of disease activity also were quantitated. When patients were grouped by the number of abnormal BAL lavage and serum markers, those patients with elevated values of five or more of these markers had significantly worse clinical disease and lower carbon monoxide diffusing capacities. These results indicate that pulmonary sarcoidosis is an immunologically heterogeneous disease and that measurement of several markers of disease activity may be required to accurately estimate the activity of the lung disease.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalSarcoidosis
Volume8
Issue number1
StatePublished - Jan 1 1991

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Bronchoalveolar Lavage
Sarcoidosis
Serum
Pulmonary Sarcoidosis
Dimercaprol
Lung
Therapeutic Irrigation
Respiratory Function Tests
Bronchoalveolar Lavage Fluid
Carbon Monoxide
Lung Diseases
Biomarkers

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

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title = "An analysis of the inter-relationships among multiple bronchoalveolar lavage and serum determinations, physiologic tests, and clinical disease activity in patients with sarcoidosis.",
abstract = "Analysis of epithelial lining fluid from the lungs of patients with sarcoidosis frequently suggests the presence of an alveolitis. Several markers of this inflammatory response were quantitated in bronchoalveolar lavage fluid and serum from 45 non-smoking patients with sarcoidosis. All markers were elevated significantly compared to those from 19 normal controls. The degree of statistical correlation among all data was assessed. Pulmonary function tests, 67Gallium lung scans, and a clinical index of disease activity also were quantitated. When patients were grouped by the number of abnormal BAL lavage and serum markers, those patients with elevated values of five or more of these markers had significantly worse clinical disease and lower carbon monoxide diffusing capacities. These results indicate that pulmonary sarcoidosis is an immunologically heterogeneous disease and that measurement of several markers of disease activity may be required to accurately estimate the activity of the lung disease.",
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An analysis of the inter-relationships among multiple bronchoalveolar lavage and serum determinations, physiologic tests, and clinical disease activity in patients with sarcoidosis. / Rankin, J. A.; Huang, S. S.; Sostman, H. D.; Gee, J. B.; Reynolds, Herbert.

In: Sarcoidosis, Vol. 8, No. 1, 01.01.1991, p. 19-28.

Research output: Contribution to journalArticle

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