TY - JOUR
T1 - An approach to classifying subjective cognitive decline in community-dwelling elders
AU - Rabin, Laura A.
AU - Wang, Cuiling
AU - Mogle, Jacqueline A.
AU - Lipton, Richard B.
AU - Derby, Carol A.
AU - Katz, Mindy J.
N1 - Funding Information:
This work was supported by National Institutes of Health grants NIA 2 P01 AG03949, NIA 1R01AG039409‐01, and NIA R21 AG056920; the Leonard and Sylvia Marx Foundation; the Czap Foundation; and NSF REU Award 1757560. The authors would like to thank the dedicated EAS participants for their time and effort in support of this research. This research was made possible through the hard work of EAS research assistants: Diane Sparracio and April Russo for assistance with participant recruitment; Betty Forro, Maria Luisa Giraldi, and Sylvia Alcala for assistance with clinical and neuropsychological assessments; and Michael Potenza for assistance with data management. All authors contributed to and approved the final manuscript.
Publisher Copyright:
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Introduction: Subjective cognitive decline (SCD) may be an early symptomatic manifestation of Alzheimer's disease, though published research largely neglects how to classify SCD in community-based studies. Methods: In neuropsychologically intact Einstein Aging Study participants (n = 1115; mean age = 78; 63% female; 30% non-White), we used Cox models to examine the association between self-perceived cognitive functioning at baseline (using three different approaches) and incident amnestic mild cognitive impairment (aMCI) with covariates of age, sex, education, race/ethnicity, general (objective) cognition, depressive symptoms, and four other SCD-related features. Results: After a median of 3 years, 198 participants developed aMCI. In models that included all the variables, self-perceived cognitive functioning was consistently associated with incident aMCI as were age, general cognition, and perceived control; apolipoprotein E (APOE) ε4 allele status was significant in one model. We set cut points that optimized the diagnostic accuracy of SCD at various time frames. Discussion: We provide an approach to SCD classification and discuss implications for cognitive aging studies.
AB - Introduction: Subjective cognitive decline (SCD) may be an early symptomatic manifestation of Alzheimer's disease, though published research largely neglects how to classify SCD in community-based studies. Methods: In neuropsychologically intact Einstein Aging Study participants (n = 1115; mean age = 78; 63% female; 30% non-White), we used Cox models to examine the association between self-perceived cognitive functioning at baseline (using three different approaches) and incident amnestic mild cognitive impairment (aMCI) with covariates of age, sex, education, race/ethnicity, general (objective) cognition, depressive symptoms, and four other SCD-related features. Results: After a median of 3 years, 198 participants developed aMCI. In models that included all the variables, self-perceived cognitive functioning was consistently associated with incident aMCI as were age, general cognition, and perceived control; apolipoprotein E (APOE) ε4 allele status was significant in one model. We set cut points that optimized the diagnostic accuracy of SCD at various time frames. Discussion: We provide an approach to SCD classification and discuss implications for cognitive aging studies.
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U2 - 10.1002/dad2.12103
DO - 10.1002/dad2.12103
M3 - Article
C2 - 33015309
AN - SCOPUS:85100474077
VL - 12
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
SN - 2352-8729
IS - 1
M1 - e12103
ER -