Abstract
The delta method is utilized to construct an asymptotic 100(1 - a)% confidence interval for the response at the stationary point of a quadratic response surface. The end-points of the interval can be found directly compared to other more computationally intense procedures that result in a conservative interval. The coverage probability associated with intervals constructed in this manner from studies with relatively small numbers of observations is investigated via a simulation study. Finally the methodology is illustrated with an example involving the evaluation of a combination of cytotoxic agents in the treatment of murine LI210 leukemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 287-301 |
| Number of pages | 15 |
| Journal | Journal of Biopharmaceutical Statistics |
| Volume | 1 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1991 |
All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Pharmacology
- Pharmacology (medical)
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Chinchilli, V., Carter, W. H., Campbell, E. D., & Breen, T. J. (1991). An asymptotic confidence interval for the response at the stationary point of a quadratic response surface. Journal of Biopharmaceutical Statistics, 1(2), 287-301. https://doi.org/10.1080/10543409108835024