An atlas of serpin conformations

James Whisstock, Richard Skinner, Arthur Lesk

Research output: Contribution to journalReview article

160 Scopus citations

Abstract

The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalTrends in Biochemical Sciences
Volume23
Issue number2
DOIs
StatePublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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